| Literature DB >> 1271380 |
A K Bhattacharyya, L J Zaneveld, B M Dragoje, G F Schumacher, J Travis.
Abstract
Twenty-two synthetic proteinase inhibitors were tested for their inhibitory properties towards human acrosin. p-Nitrophenyl-p1-guanidino benzoate (NPGB) was the most effective (K1 value of 1-5 X 10(-8) M), producing a non-competitive type of inhibition in contrast to all other inhibitors which showed a competitive type of inhibition. The Michaelis constant for human acrosin on BAEE at pH 8-1 was calculated to be 4-25 X 10(-5) M.Entities:
Keywords: Biology; Economic Factors; Enzyme Inhibitors--administraction and dosage; Enzyme Inhibitors--side effects; Enzymes; Enzymes And Enzyme Inhibitors; Fertilization; Physiology; Reproduction; Research And Development; Sperm Capacitation; Technology
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Year: 1976 PMID： 1271380 DOI： 10.1530/jrf.0.0470097
Source DB: PubMed Journal: J Reprod Fertil ISSN： 0022-4251