Literature DB >> 12713420

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata.

Masaki Fujita1, Yoichi Nakao, Shigeki Matsunaga, Rob W M van Soest, Yoshifumi Itoh, Motoharu Seiki, Nobuhiro Fusetani.   

Abstract

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.

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Year:  2003        PMID： 12713420     DOI： 10.1021/np020572s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

Review 1.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

Review 2.  Anticancer activity of natural and synthetic acetylenic lipids.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2006-10       Impact factor: 1.880

3.  Directed evolution of protease beacons that enable sensitive detection of endogenous MT1-MMP activity in tumor cell lines.

Authors:  Abeer Jabaiah; Patrick S Daugherty
Journal:  Chem Biol       Date:  2011-03-25

Review 4.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

Review 5.  Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects.

Authors:  Chen Zhang; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2009-03-31       Impact factor: 5.118

Review 6.  Protease inhibitors and their peptidomimetic derivatives as potential drugs.

Authors:  Georgie Fear; Slavko Komarnytsky; Ilya Raskin
Journal:  Pharmacol Ther       Date:  2006-09-22       Impact factor: 12.310

Review 7.  Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data.

Authors:  Lucas Hilário Nogueira de Sousa; Rusceli Diego de Araújo; Déborah Sousa-Fontoura; Fabrício Gava Menezes; Renata Mendonça Araújo
Journal:  Mar Drugs       Date:  2021-11-26       Impact factor: 5.118
  7 in total

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