| Literature DB >> 12713410 |
Kazuyoshi Kawazoe1, Yoshiko Tsubouchi, Norasyikin Abdullah, Yoshihisa Takaishi, Hirohumi Shibata, Tomihiko Higuti, Hitoshi Hori, Makoto Ogawa.
Abstract
A new secoguaianolide sesquiterpene (1) was isolated along with its three stereoisomers (2-4) from the nonmedicinal plant Artemisia gilvescens. The structure of 1 was elucidated to be (4S,5S)-dihydro-5-[(1R,2S)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone on the basis of 2D NMR and other spectroscopic evidence. Five known sesquiterpenoids were also isolated from this plant, and one of them (5) showed activity against methicillin-resistant Staphylococcus aureus (MRSA).Entities:
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Year: 2003 PMID： 12713410 DOI： 10.1021/np020593m
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050