Literature DB >> 12713375

Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

Mao S Cheng1, Qian L Wang, Quan Tian, Hong Y Song, Yong X Liu, Qiang Li, Xin Xu, Hong D Miao, Xin S Yao, Zhen Yang.   

Abstract

Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3 beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.

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Year:  2003        PMID: 12713375     DOI: 10.1021/jo020683w

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  5 in total

1.  Isolation and characterization of diosgenin from in vitro cultured tissues of Helicteres isora L.

Authors:  Harshal A Deshpande; Sanjivani R Bhalsing
Journal:  Physiol Mol Biol Plants       Date:  2013-11-22

2.  Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.

Authors:  Guofeng Gu; Yuguo Du; Robert J Linhardt
Journal:  J Org Chem       Date:  2004-08-06       Impact factor: 4.354

3.  Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses.

Authors:  Rongli Zhang; Shila Gilbert; Xinsheng Yao; Jefferson Vallance; Kris Steinbrecher; Richard Moriggl; Dongsheng Zhang; Madhu Eluri; Haifeng Chen; Huiqing Cao; Noah Shroyer; Lee Denson; Xiaonan Han
Journal:  Pharmacol Res Perspect       Date:  2015-02-10

4.  Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer.

Authors:  LianYu Chen; Chien-Shan Cheng; HuiFeng Gao; Ling Zhan; FengJiao Wang; Chao Qu; Ye Li; Peng Wang; Hao Chen; ZhiQiang Meng; LuMing Liu; HaiFeng Chen; Zhen Chen
Journal:  Evid Based Complement Alternat Med       Date:  2018-03-15       Impact factor: 2.629

5.  Photooxidation of thiosaccharides mediated by sensitizers in aerobic and environmentally friendly conditions.

Authors:  Miqueas G Traverssi; Alicia B Peñéñory; Oscar Varela; Juan P Colomer
Journal:  RSC Adv       Date:  2021-03-01       Impact factor: 3.361

  5 in total

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