Literature DB >> 127127

Decreased glycolytic flux rate in the isolated perfused rat brain after pretreatment with 6-aminonicotinamide.

J Krieglstein, R Stock.   

Abstract

Cerebral energy metabolism was studied in the isolated perfused rat brain after 6-aminonicotinamide (6-AN; 35 mg/kg i.p.) administered to the intact animals 7 hrs before perfusion was started. The metabolic alterations in the isolated rat brains were such as reported for rat and mouse brain in vivo: Inhibition of 6-phosphogluconate dehydrogenase was followed by an accumulation of 6-phosphogluconate, leading to a decreased activity of glucosephosphate isomerse. This was reflected by increased levels of glucose and glucose 6-phosphate and decreased levels of fructose 6-phosphate, pyruvate and lactate. Since the concentration of lactate in the perfusate of the isolated brain was also lowered, 6-AN must have reduced the glycolytic flux rate.

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Year:  1975        PMID： 127127     DOI： 10.1007/bf00510561

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  12 in total

1.  6-Aminonicotinamide and acute degenerative changes in the central nervous system.

Authors:  S S STERNBERG; F S PHILIPS
Journal:  Science       Date:  1958-03-21       Impact factor: 47.728

2.  Blocking of pentose phosphate pathway in the brain of rats by 6-aminonicotinamide.

Authors:  H Herken; K Lange
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1969

3.  Brain disorders induced by pharmacological blockade of the pentose phosphate pathway.

Authors:  H Herken; K Lange; H Kolbe
Journal:  Biochem Biophys Res Commun       Date:  1969-07-07       Impact factor: 3.575

4.  [Experimental myelopathy--biochemical basis of its cellular pathogenesis (author's transl)].

Authors:  H Herken; K Keller; H Kolbe; K Lange; H Schneider
Journal:  Klin Wochenschr       Date:  1973-07-01

5.  Behaviour of the glycolytic system of rat brain and kidney in vivo after in hibition of the glucosephosphate isomerase. II. Substrate concentrations under the influence of ischemia, 6-aminonicotinamide, and 2-deoxyglucose.

Authors:  K Keller; H Kolbe; K Lange; H Herken
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1972-09

6.  Comparison of the effects of chloral hydrate and trichlorethanol on the EEG of the isolated perfused rat brain.

Authors:  J Grüner; J Krieglstein; H Rieger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

7.  [Brain carbohydrate metabolism following blockade of the pentose phosphate pathway by 6-aminonicotinamide].

Authors:  K Lange; H Kolbe; K Keller; H Herken
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1970-10

8.  [Two devices for perfusion of isolated rat brain].

Authors:  W Fleck; J Krieglstein; W Urban
Journal:  Arzneimittelforschung       Date:  1972-07

9.  Cerebral energy reserves and glycolysis in neural tissue of 6-aminonicotinamide-treated mice.

Authors:  F C Kauffman; E C Johnson
Journal:  J Neurobiol       Date:  1974

10.  An isolated, perfused rat brain preparation, its spontaneous and stimulated activity.

Authors:  R K Andjus; K Suhara; H A Sloviter
Journal:  J Appl Physiol       Date:  1967-05       Impact factor: 3.531
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  8 in total

1.  Phenobarbital and 6-aminonicotinamide effect on cerebral enzymatic activities related to energy metabolism in different rat brain areas.

Authors:  F Marzatico; F Dagani; D Curti; G Benzi
Journal:  Neurochem Res       Date:  1987-01       Impact factor: 3.996

2.  Oxidative metabolism and acetylcholine synthesis during acetylpyridine treatment.

Authors:  G E Gibson; J P Blass
Journal:  Neurochem Res       Date:  1985-04       Impact factor: 3.996

3.  Correlated changes in neuronal cerebral rat brain RNA synthesis and hypo- and hypermotoric disorders induced by 6-aminonicotinamide (6-AN).

Authors:  E Knoll-Köhler; F Wojnorowicz; H J Sarkander
Journal:  Exp Brain Res       Date:  1980-01       Impact factor: 1.972

4.  Inhibition of biopterin synthesis and DOPA production in PC-12 pheochromocytoma cells induced by 6-aminonicotinamide.

Authors:  W Jung; H Herken
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

5.  Decreased GABA and glutamate concentration in rat brain after treatment with 6-aminonicotinamide.

Authors:  L Bielicki; J Krieglstein
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-08       Impact factor: 3.000

6.  Spastic paresis after 6-aminonicotinamide: metabolic disorders in the spinal cord and electromyographically recorded changes in the hind limbs of rats.

Authors:  H Herken; G Meyer-Estorf; K Halbhübner; D Loos
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-06       Impact factor: 3.000

7.  Inhibition of glucose phosphorylation in rat brain by thiopental.

Authors:  L Bielicki
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

8.  Hypoxia drives the assembly of the multienzyme purinosome complex.

Authors:  Cyrielle Doigneaux; Anthony M Pedley; Ishna N Mistry; Monika Papayova; Stephen J Benkovic; Ali Tavassoli
Journal:  J Biol Chem       Date:  2020-05-21       Impact factor: 5.157
  8 in total

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