Literature DB >> 1271266

Simple transformation method for predicting plasma drug profiles from dissolution rates.

D P Vaughan, R H Leach.   

Abstract

A transformation factor is described which related in vitro drug dissolution from a preparation to the corresponding in vivo plasma drug concentrations. This factor, derived from the dissolution profile and the corresponding in vivo plasma concentration of a single formulation, was used to predict plasma concentration profiles of similar formulations simply from dissolution data.

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Year:  1976        PMID： 1271266     DOI： 10.1002/jps.2600650432

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  3 in total

1.  Investigating relationships between in vivo and in vitro pharmacological variables for the purpose of prediction.

Authors:  W R Fairweather
Journal:  J Pharmacokinet Biopharm       Date:  1977-08

2.  The in vitro development of extended-release solid oral dosage forms.

Authors:  L J Leeson; D Adair; J Clevenger; N Chiang
Journal:  J Pharmacokinet Biopharm       Date:  1985-10

3.  Concentration profile for the dissolution of drug tablets undergoing simultaneous degradation.

Authors:  H S Chen; S Y Chang; T L Evans; J F Gross
Journal:  J Pharmacokinet Biopharm       Date:  1980-12
  3 in total

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