[Microbial biocenosis in the mucous membranes of the nose and the middle ear in patients with purulent otitis].

25 biocenoses of the microflora of the mucous membranes of the nose and the middle ear in patients having acute and chronic purulent otitis media (epi- and mesotympanitis) were studied. The dynamic study was carried out at the peak of the manifestations of clinical symptoms and on convalescence or improvement of the state of patients. In the process of convalescence the normalization of the composition of the microflora of the nose and the middle ear was found to occur in patients having acute otitis as compared with those having chronic otitis. In chronic otitis dysbiosis was observed in the microflora of the nose and the middle ear (the preservation of Staphylococcus aureus and enterobacterial strains with increased capacity for persistence). Correlation between the taxonomic composition and the biological properties of the microflora of the nose and the middle ear was established. Changes in the properties of individual strains of the microflora in the bacterial interaction of symbionts were more pronounced in the acute form of otitis than in the chronic one.