OBJECTIVE: This study was undertaken to determine the frequency of growth impairment in neonates with encephalopathy. STUDY DESIGN: In a case-control design, neonates with neonatal encephalopathy (NE) meeting criteria for an acute intrapartum hypoxic event (IHE, n = 21) and those who did not meet these criteria (n = 20) were compared with controls. The controls were 42 neonates without complications matched 2:1 for gestational age with IHE cases. The percentile of growth potential, a measure of the weight expected in the absence of pathological conditions, was calculated for each fetus. RESULTS: More neonates with NE with and without IHE were below the 10th percentile of growth potential compared with controls (7/21 [33%] and 6/20 [30%] vs 1/42 [2.4%], odds ratio [95% CI] = 20.5 [2.2-114.0] and 17.6 [1.8-102.5], respectively). These associations remained significant after controlling for gestational age and birth weight. CONCLUSION: A large proportion of neonates with NE demonstrate signs of antepartum injury reflected in the impairment of their growth. This association was similar in the presence or absence of IHE, indicating that antepartum injury has a causative rather than predisposing character in many cases of IHE.
OBJECTIVE: This study was undertaken to determine the frequency of growth impairment in neonates with encephalopathy. STUDY DESIGN: In a case-control design, neonates with neonatal encephalopathy (NE) meeting criteria for an acute intrapartum hypoxic event (IHE, n = 21) and those who did not meet these criteria (n = 20) were compared with controls. The controls were 42 neonates without complications matched 2:1 for gestational age with IHE cases. The percentile of growth potential, a measure of the weight expected in the absence of pathological conditions, was calculated for each fetus. RESULTS: More neonates with NE with and without IHE were below the 10th percentile of growth potential compared with controls (7/21 [33%] and 6/20 [30%] vs 1/42 [2.4%], odds ratio [95% CI] = 20.5 [2.2-114.0] and 17.6 [1.8-102.5], respectively). These associations remained significant after controlling for gestational age and birth weight. CONCLUSION: A large proportion of neonates with NE demonstrate signs of antepartum injury reflected in the impairment of their growth. This association was similar in the presence or absence of IHE, indicating that antepartum injury has a causative rather than predisposing character in many cases of IHE.
Authors: Thang Nguyen Manh; Nhon Bui Van; Huyen Le Thi; Long Vo Hoang; Hao Nguyen Si Anh; Huong Trinh Thi Thu; Thuc Nguyen Xuan; Nga Vu Thi; Le Bui Minh; Dinh-Toi Chu Journal: Int J Environ Res Public Health Date: 2019-06-12 Impact factor: 3.390
Authors: Joshua P Vogel; Valerie Vannevel; Gianna Robbers; George Gwako; Tina Lavin; Abiodun Adanikin; Tsakane Hlongwane; Robert C Pattinson; Zahida P Qureshi; Olufemi T Oladapo Journal: Reprod Health Date: 2021-02-12 Impact factor: 3.223
Authors: Valerie Vannevel; Joshua P Vogel; Robert C Pattinson; Richard Adanu; Umesh Charantimath; Shivaprasad S Goudar; George Gwako; Avinash Kavi; Ernest Maya; Alfred Osoti; Yeshita Pujar; Zahida P Qureshi; Stephen Rulisa; Tanita Botha; Olufemi T Oladapo Journal: BMJ Open Date: 2022-03-16 Impact factor: 2.692
Authors: Natasha L Pritchard; Susan P Walker; Alexandra R Mitchell; Stephen Tong; Anthea C Lindquist Journal: PLoS One Date: 2022-10-10 Impact factor: 3.752