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Literature DB >> 12711216

Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

Marjori A Matzke¹, M Florian Mette, Tatsuo Kanno, Antonius J M Matzke.

Abstract

The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.

Entities: Disease

Mesh：

Year: 2003 PMID： 12711216 DOI： 10.1016/s0168-9525(03)00057-x

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

26 in total

Review 1. In search of the molecular basis of heterosis.

Authors: James A Birchler; Donald L Auger; Nicole C Riddle
Journal: Plant Cell Date: 2003-10 Impact factor: 11.277

2. Phenotypic consequences of aneuploidy in Arabidopsis thaliana.

Authors: Isabelle M Henry; Brian P Dilkes; Eric S Miller; Diana Burkart-Waco; Luca Comai
Journal: Genetics Date: 2010-09-27 Impact factor: 4.562

3. Gene expression analysis of the function of the male-specific lethal complex in Drosophila.

Authors: Manika Pal Bhadra; Utpal Bhadra; Joydeep Kundu; James A Birchler
Journal: Genetics Date: 2005-02-16 Impact factor: 4.562

4. Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.

Authors: Soma Banerjee; Kyungjae Myung
Journal: Eukaryot Cell Date: 2004-12

10. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells.

Authors: Madhvi B Upender; Jens K Habermann; Lisa M McShane; Edward L Korn; J Carl Barrett; Michael J Difilippantonio; Thomas Ried
Journal: Cancer Res Date: 2004-10-01 Impact factor: 12.701

Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

Review 1. In search of the molecular basis of heterosis.

2. Phenotypic consequences of aneuploidy in Arabidopsis thaliana.

3. Gene expression analysis of the function of the male-specific lethal complex in Drosophila.

4. Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.

Review 5. Maturation of the kinetochore-microtubule interface and the meaning of metaphase.

6. Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.

7. Epigenetic Therapy in Breast Cancer.

8. Aneuploidy causes tissue-specific qualitative changes in global gene expression patterns in maize.

9. Meiotically asynapsis-induced aneuploidy in autopolyploid Arabidopsis thaliana.

10. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells.