Literature DB >> 12711144

Phenolic glycosides from Symplocos racemosa: natural inhibitors of phosphodiesterase I.

Viqar Uddin Ahmad1, Muhammad Athar Abbasi, Hidayat Hussain, Muhammad Nadeem Akhtar, Umar Farooq, Naheed Fatima, M Iqbal Choudhary.   

Abstract

One new phenolic glycoside named benzoylsalireposide (1) along with one known phenolic glycoside named salireposide (2) have been isolated from Symplocos racemosa. Four other known compounds i.e. beta-amyrin (3), oleonolic acid (4), beta-sitosterol (5) and beta-sitosterol glycoside (6) were also isolated from this plant. The structure elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The compound 1 and 2 showed inhibitory activity against snake venom phosphodiesterase I.

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Year:  2003        PMID： 12711144     DOI： 10.1016/s0031-9422(03)00075-x

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  8 in total

1.  Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats.

Authors:  Christudas Sunil; Savarimuthu Ignacimuthu; Chidambaram Kumarappan
Journal:  J Nat Med       Date:  2011-06-18       Impact factor: 2.343

2.  Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations.

Authors:  Asaad Khalid; Mohnad Abdalla; Maria Saeed; Muhammad Nabeel Ghayur; Surya Kant Kalauni; Mohammed Albratty; Hassan A Alhazmi; Mohammed Ahmed Mesaik; Anwarul Hassan Gilani; Zaheer Ul-Haq
Journal:  Molecules       Date:  2022-05-24       Impact factor: 4.927

Review 3.  Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations.

Authors:  Asenate A X Adrião; Aline O Dos Santos; Emilly J S P de Lima; Jéssica B Maciel; Weider H P Paz; Felipe M A da Silva; Manuela B Pucca; Ana M Moura-da-Silva; Wuelton M Monteiro; Marco A Sartim; Hector H F Koolen
Journal:  Front Immunol       Date:  2022-05-09       Impact factor: 8.786

4.  Do herbal medicines have potential for managing snake bite envenomation?

Authors:  Y K Gupta; S S Peshin
Journal:  Toxicol Int       Date:  2012-05

5.  Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls.

Authors:  Abdur Rauf; Muhammad Saleem; Ghias Uddin; Bina S Siddiqui; Haroon Khan; Muslim Raza; Syeda Zehra Hamid; Ajmal Khan; Francesco Maione; Nicola Mascolo; Vincenzo De Feo
Journal:  Evid Based Complement Alternat Med       Date:  2015-04-05       Impact factor: 2.629

6.  Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties.

Authors:  Yahia N Mabkhot; Salim S Al-Showiman; Saied M Soliman; Hazem A Ghabbour; Murad A AlDamen; Mohammad S Mubarak
Journal:  Chem Cent J       Date:  2017-06-09       Impact factor: 4.215

7.  Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1.

Authors:  Assem Barakat; Mohammad Shahidul Islam; Hussien Mansur Ghawas; Abdullah Mohammed Al-Majid; Fardous F El-Senduny; Farid A Badria; Yaseen A M M Elshaier; Hazem A Ghabbour
Journal:  RSC Adv       Date:  2018-04-17       Impact factor: 4.036

8.  A new phenolic amide from the roots of Paris verticillata.

Authors:  Kyu Ha Lee; Min Cheol Yang; Ki Hyun Kim; Hak Cheol Kwon; Sang Un Choi; Kang Ro Lee
Journal:  Molecules       Date:  2008-01-16       Impact factor: 4.411
  8 in total

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