Literature DB >> 12710731

An antiviral meliacarpin from leaves of Melia azedarach L.

Laura E Alché1, Guillermo Assad Ferek, Milena Meo, Celia E Coto, Marta S Maier.   

Abstract

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.

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Year:  2003        PMID： 12710731     DOI： 10.1515/znc-2003-3-413

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  8 in total

1.  Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway.

Authors:  Carlos Alberto Bueno; Flavia Mariana Michelini; Mariano Walter Pertino; Catalina Arredondo Gómez; Guillermo Schmeda-Hirschmann; Laura Edith Alché
Journal:  Med Microbiol Immunol       Date:  2014-12-21       Impact factor: 3.402

2.  The synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin.

Authors:  Erina Petrera; Celia E Coto
Journal:  Virol J       Date:  2006-06-13       Impact factor: 4.099

3.  Naturally occurring compounds elicit HIV-1 replication in chronically infected promonocytic cells.

Authors:  Andrea Alejandra Barquero; María Eugenia Dávola; Diego Ariel Riva; Susana Esther Mersich; Laura Edith Alché
Journal:  Biomed Res Int       Date:  2014-05-12       Impact factor: 3.411

4.  Growth dynamics of different half-sib families of Melia azedarach Linn.

Authors:  Sanjeev Kumar Chauhan; Ashok Kumar Dhakad; Rajni Sharma
Journal:  PLoS One       Date:  2018-11-12       Impact factor: 3.240

5.  Repellent and Lethal Activities of Extracts From Fruits of Chinaberry (Melia azedarach L., Meliaceae) Against Triatoma infestans.

Authors:  Martín Dadé; Pedro Zeinsteger; Facundo Bozzolo; Nora Mestorino
Journal:  Front Vet Sci       Date:  2018-07-26

6.  Antihypertensive Activity in High Salt-Induced Hypertensive Rats and LC-MS/MS-Based Phytochemical Profiling of Melia azedarach L. (Meliaceae) Leaves.

Authors:  Anam Saeed; Kashif Bashir; Abdul Jabbar Shah; Rahila Qayyum; Taous Khan
Journal:  Biomed Res Int       Date:  2022-07-26       Impact factor: 3.246

7.  Functional growth inhibition of influenza A and B viruses by liquid and powder components of leaves from the subtropical plant Melia azedarach L.

Authors:  Kuniaki Nerome; Kazufumi Shimizu; Shiori Zukeran; Yasuhiro Igarashi; Kazumichi Kuroda; Shigeo Sugita; Toshikatsu Shibata; Yasuhiko Ito; Reiko Nerome
Journal:  Arch Virol       Date:  2018-04-09       Impact factor: 2.574

8.  A natural tetranortriterpenoid with immunomodulating properties as a potential anti-HSV agent.

Authors:  Carlos A Bueno; Andrea A Barquero; Hernán Di Cónsoli; Marta S Maier; Laura E Alché
Journal:  Virus Res       Date:  2009-01-20       Impact factor: 3.303
  8 in total

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