| Literature DB >> 12710593 |
Itaru Narushima1, Taizo Kita, Kaoru Kubo, Yukio Yonetani, Chikako Momochi, Ichigo Yoshikawa, Norikazu Ohno, Toshikatsu Nakashima.
Abstract
The effects of intracisternal administration of endothelin-1 on blood-brain barrier permeability were examined in dogs and rats. Single doses of endothelin-1 elevated blood-brain barrier permeability about two times compared with control groups in both species. However, repeated dosing with endothelin-1 at a 24 hr intervals caused a highly enhanced disruption of blood-brain barrier permeability in dogs, but not in rats, whereas the repeated administration with a 48 hr interval markedly increased the blood-brain barrier permeability in both species of animals (dogs: 923%, rats: more than 661%). Moreover, this abnormally enhanced permeability of blood-brain barrier in dogs was completely blocked by pretreatment with the endothelin ET-A receptor selective antagonist, S-0139, administered prior to either the first or second dosing with endothelin-1. From these results, we conclude that a repeated attack of endothelin-1 from the adventitial site of brain blood vessels produces a severe disruption of blood-brain barrier permeability through an endothelin ET-A receptor-mediated process.Entities:
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Year: 2003 PMID： 12710593 DOI： 10.1034/j.1600-0773.2003.920104.x
Source DB: PubMed Journal: Pharmacol Toxicol ISSN： 0901-9928