Literature DB >> 1271050

Gammahydroxy butyric acid: cardiovascular effects in the rat.

C Gomes, C Flygt, M Henning, L Norin, T H Svensson, G Trolin.   

Abstract

Gammahydroxybutyric acid (GHBA) 1 g/kg i.p. induced a marked and sustained increase in heart frequency and blood pressure in the rats. These effects of GHBA were abolished by a high spinal transection. In biochemical experiments GHBA in the same dose increased the turnover of brain noradrenaline but decreased the turnover of dopamine. The cardiovascular effects of GHBA are suggested to be of central origin, and possibly involve central noradrenergic mechanisms.

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Year:  1976        PMID： 1271050     DOI： 10.1007/BF01262970

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  17 in total

1.  Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine.

Authors:  T H Svensson; B S Bunney; G K Aghajanian
Journal:  Brain Res       Date:  1975-07-11       Impact factor: 3.252

2.  Some effects of sodium gamma-hydroxybutyrate on the central nervous system.

Authors:  A B DRAKONTIDES; J A SCHNEIDER; W H FUNDERBURK
Journal:  J Pharmacol Exp Ther       Date:  1962-03       Impact factor: 4.030

3.  Involvement of alpha-adrenergic receptors at different levels of the central nervous system in the regulation of blood pressure and heart frequency.

Authors:  G G Trolin
Journal:  Acta Physiol Scand Suppl       Date:  1975

4.  Evidence for a central noradrenaline receptor stimulation by clonidine.

Authors:  N E Andén; H Corrodi; K Fuxe; B Hökfelt; T Hökfelt; C Rydin; T Svensson
Journal:  Life Sci       Date:  1970-05-01       Impact factor: 5.037

5.  Effect of pentobarbitone and diethyl ether on the synthesis of monoamines in rat brain.

Authors:  M Lindqvist; W Kehr; A Carlsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

6.  Increase in brain dopamine after axotomy or treatment with gammahydroxybutyric acid due to elimination of the nerve impulse flow.

Authors:  G Stock; T Magnusson; N E Andén
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

7.  Superfusion of the hypothalamus with gamma-aminobutyric acid. Effect on release of noradrenaline and blood pressure.

Authors:  A Philippu; H Przuntek; W Roensberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

8.  The determination of dopamine by a modification of the dihydroxyindole fluorimetric assay.

Authors:  C V Atack
Journal:  Br J Pharmacol       Date:  1973-08       Impact factor: 8.739

9.  Gammahydroxybutyric acid.

Authors:  M D Vickers
Journal:  Int Anesthesiol Clin       Date:  1969

Review 10.  Central sympathetic transmitters and hypertension.

Authors:  M Henning
Journal:  Clin Sci Mol Med Suppl       Date:  1975-06
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  4 in total

1.  Effects of morphine on central catecholamine turnover, blood pressure and heart rate in the rat.

Authors:  C Gomes; T H Svensson; G Trolin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-08       Impact factor: 3.000

2.  Evidence for involvement of central noradrenergic neurons in the cardiovascular depression induced by morphine in the rat.

Authors:  C Gomes; T H Svensson; G Trolin
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

3.  Cardiovascular responses elicited by intragastric administration of BDL and GHB.

Authors:  Alissa R Hicks; Kurt J Varner
Journal:  J Recept Signal Transduct Res       Date:  2008       Impact factor: 2.092

4.  Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.

Authors:  S R Pagliusi; C Gomes; J R Leite; G Trolin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-04       Impact factor: 3.000
  4 in total

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