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Literature DB >> 12709907

Ostruthin: an antimycobacterial coumarin from the roots of Peucedanum ostruthium.

Andreas Schinkovitz, Simon Gibbons, Michael Stavri, Michael J Cocksedge, Franz Bucar.

Abstract

Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 microM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).

Entities: Chemical Species

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Year: 2003 PMID： 12709907 DOI： 10.1055/s-2003-38876

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

21 in total

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