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Literature DB >> 12709354

Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release.

Elizabeth A Coyle¹, Raymond Cha, Michael J Rybak.

Abstract

An in vitro model was used to compare the effects of linezolid, clindamycin, and penicillin, alone and in combination, on streptococcal pyrogenic exotoxin A (SPE A) release against virulent group A streptococci (GAS). All regimens exhibited lower (P < 0.05) SPE A release at 1 h than those with penicillin alone. Linezolid and clindamycin, alone or in combination with penicillin, may optimize the treatment of GAS infections by reducing bacterial burden and exotoxin release.

Entities: Chemical Disease Species

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Year: 2003 PMID： 12709354 PMCID： PMC153301 DOI： 10.1128/AAC.47.5.1752-1755.2003

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

23 in total

1. Sensitive enzyme-linked immunosorbent assays for the detection of bacterial superantigens and antibodies against them in human plasma.

Authors: K Miwa; M Fukuyama; R Sakai; S Shimizu; N Ida; M Endo; H Igarashi
Journal: Microbiol Immunol Date: 2000 Impact factor: 1.955

2. The effect of roxithromycin on the virulence of gram-positive cocci.

Authors: C G Gemmell; M McLeod
Journal: Diagn Microbiol Infect Dis Date: 1992 May-Jun Impact factor: 2.803

3. Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid.

Authors: Curtis G Gemmell; Charles W Ford
Journal: J Antimicrob Chemother Date: 2002-11 Impact factor: 5.790

4. Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness.

Authors: P K Lee; P M Schlievert
Journal: J Clin Microbiol Date: 1989-08 Impact factor: 5.948

5. In-vitro model for simultaneous simulation of the serum kinetics of two drugs with different half-lives.

Authors: J Blaser
Journal: J Antimicrob Chemother Date: 1985-01 Impact factor: 5.790

6. Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome.

Authors: A R Hauser; D L Stevens; E L Kaplan; P M Schlievert
Journal: J Clin Microbiol Date: 1991-08 Impact factor: 5.948

7. A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S, and pyrogenic exotoxin B.

Authors: A Heath; V J DiRita; N L Barg; N C Engleberg
Journal: Infect Immun Date: 1999-10 Impact factor: 3.441

8. Effect of antibiotics on toxin production and viability of Clostridium perfringens.

Authors: D L Stevens; K A Maier; J E Mitten
Journal: Antimicrob Agents Chemother Date: 1987-02 Impact factor: 5.191

9. The Eagle effect revisited: efficacy of clindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis.

Authors: D L Stevens; A E Gibbons; R Bergstrom; V Winn
Journal: J Infect Dis Date: 1988-07 Impact factor: 5.226

10. Potentiation of opsonization and phagocytosis of Streptococcus pyogenes following growth in the presence of clindamycin.

Authors: C G Gemmell; P K Peterson; D Schmeling; Y Kim; J Mathews; L Wannamaker; P G Quie
Journal: J Clin Invest Date: 1981-05 Impact factor: 14.808

33 in total

Influences of linezolid, penicillin, and clindamycin, alone and in combination, on streptococcal pyrogenic exotoxin a release.

1. Sensitive enzyme-linked immunosorbent assays for the detection of bacterial superantigens and antibodies against them in human plasma.

2. The effect of roxithromycin on the virulence of gram-positive cocci.

3. Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid.

4. Quantification and toxicity of group A streptococcal pyrogenic exotoxins in an animal model of toxic shock syndrome-like illness.

5. In-vitro model for simultaneous simulation of the serum kinetics of two drugs with different half-lives.

6. Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome.

7. A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S, and pyrogenic exotoxin B.

8. Effect of antibiotics on toxin production and viability of Clostridium perfringens.

9. The Eagle effect revisited: efficacy of clindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis.

10. Potentiation of opsonization and phagocytosis of Streptococcus pyogenes following growth in the presence of clindamycin.

Review 1. The Streptococcus pyogenes proteome: maps, virulence factors and vaccine candidates.

Review 2. Streptococcus dysgalactiae subsp. equisimilis bacteremia: an emerging infection.

3. Severe invasive beta haemolytic group A streptococcal cellulitis and eyelid necrosis treated with linezolid.

4. Growth phase-dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes.

5. Effect of antibiotics on group A Streptococcus exoprotein production analyzed by two-dimensional gel electrophoresis.

6. Understanding toxic shock syndrome.

7. Antibiotic efficacy is linked to bacterial cellular respiration.

Review 8. The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus.

Review 9. Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review.

10. Group G streptococcal sepsis, septic arthritis and myositis in a patient with severe oral ulcerations.