Literature DB >> 12708754

Role of BSP/bilirubin binding protein on p-aminohippurate transport in rat kidney.

Adriana M Torres1, Myriam MacLaughlin, Nora B Quaglia, Wolfgang Stremmel.   

Abstract

BSP/Bilirubin binding protein (BBBP) is a protein located on the sinusoidal membrane of the liver that transport several organic anions. The aim of this investigation was to determine whether BBBP is present in the kidney and its role in p-aminohippurate transport (PAH). Anti-BBBP antibodies inhibited PAH uptake in brush border membrane vesicles (BBMV) and Na(+)-independent PAH uptake in basolateral membrane vesicles (BLMV). Western blot studies revealed positivity to antiBBBP antibodies in both BBMV and BLMV. So BBBP is also expressed in the kidneys and accounts, at least in part, for the renal tubular transport of PAH.

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Year:  2003        PMID： 12708754     DOI： 10.1023/a:1022833713727

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  42 in total

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Journal:  Pflugers Arch       Date:  1993-05       Impact factor: 3.657

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Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

8.  Impairment of cellular redox status and membrane protein activities in kidneys from rats with ischemic acute renal failure.

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Journal:  Biochim Biophys Acta       Date:  1998-08-14

9.  Physicochemical and immunohistological studies of a sulfobromophthalein- and bilirubin-binding protein from rat liver plasma membranes.

Authors:  W Stremmel; M A Gerber; V Glezerov; S N Thung; S Kochwa; P D Berk
Journal:  J Clin Invest       Date:  1983-06       Impact factor: 14.808

10.  Difference in hepatic uptake of tetra- and di-bromosulfophthalein in rat. Role of hydrophobicity, binding to plasma proteins and affinity for plasma membrane carrier protein.

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Journal:  Biochem Pharmacol       Date:  1993-09-01       Impact factor: 5.858
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  5 in total

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3.  Modulation of biotransformation systems and ABC transporters by benznidazole in rats.

Authors:  Virginia G Perdomo; Juan P Rigalli; Silvina S M Villanueva; María L Ruiz; Marcelo G Luquita; Claudia G Echenique; Viviana A Catania
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4.  Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury.

Authors:  Gisela Di Giusto; Naohiko Anzai; Hitoshi Endou; Adriana M Torres
Journal:  J Histochem Cytochem       Date:  2008-09-15       Impact factor: 2.479

5.  Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1.

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  5 in total

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