BACKGROUND: Current therapies for PD ameliorate symptoms in the early phases of disease but become less effective over time, as the underlying disease progresses. Therapies that slow the progression of PD are needed. However, there have been relatively few clinical trials aimed at demonstrating neuroprotection. The authors sought to identify potential neuroprotective agents for testing in clinical trials. METHODS: First a broad array of compounds were identified by working with clinicians and researchers in academics and industry. Specific criteria were drafted for drug evaluation, including scientific rationale, blood-brain barrier penetration, safety and tolerability, and evidence of efficacy in animal models or humans. Agents were prioritized based on these criteria. RESULTS: The authors identified 59 potential neuroprotective compounds, proposed by 42 clinicians and scientists from 13 countries. After systematic reviews using the specified criteria they found 12 compounds to be attractive candidates for further clinical trials in PD. CONCLUSIONS: Several potential neuroprotective compounds, representing a wide range of mechanisms, are available and merit further investigation in PD.
BACKGROUND: Current therapies for PD ameliorate symptoms in the early phases of disease but become less effective over time, as the underlying disease progresses. Therapies that slow the progression of PD are needed. However, there have been relatively few clinical trials aimed at demonstrating neuroprotection. The authors sought to identify potential neuroprotective agents for testing in clinical trials. METHODS: First a broad array of compounds were identified by working with clinicians and researchers in academics and industry. Specific criteria were drafted for drug evaluation, including scientific rationale, blood-brain barrier penetration, safety and tolerability, and evidence of efficacy in animal models or humans. Agents were prioritized based on these criteria. RESULTS: The authors identified 59 potential neuroprotective compounds, proposed by 42 clinicians and scientists from 13 countries. After systematic reviews using the specified criteria they found 12 compounds to be attractive candidates for further clinical trials in PD. CONCLUSIONS: Several potential neuroprotective compounds, representing a wide range of mechanisms, are available and merit further investigation in PD.
Authors: Karl Kieburtz; Barbara C Tilley; Jordan J Elm; Debra Babcock; Robert Hauser; G Webster Ross; Alicia H Augustine; Erika U Augustine; Michael J Aminoff; Ivan G Bodis-Wollner; James Boyd; Franca Cambi; Kelvin Chou; Chadwick W Christine; Michelle Cines; Nabila Dahodwala; Lorelei Derwent; Richard B Dewey; Katherine Hawthorne; David J Houghton; Cornelia Kamp; Maureen Leehey; Mark F Lew; Grace S Lin Liang; Sheng T Luo; Zoltan Mari; John C Morgan; Sotirios Parashos; Adriana Pérez; Helen Petrovitch; Suja Rajan; Sue Reichwein; Jessie Tatsuno Roth; Jay S Schneider; Kathleen M Shannon; David K Simon; Tanya Simuni; Carlos Singer; Lewis Sudarsky; Caroline M Tanner; Chizoba C Umeh; Karen Williams; Anne-Marie Wills Journal: JAMA Date: 2015-02-10 Impact factor: 56.272
Authors: David A Price; Alex A Martinez; Alexandre Seillier; Wouter Koek; Yolanda Acosta; Elizabeth Fernandez; Randy Strong; Beat Lutz; Giovanni Marsicano; James L Roberts; Andrea Giuffrida Journal: Eur J Neurosci Date: 2009-05-21 Impact factor: 3.386