OBJECTIVE: To estimate the prevalence and resistance patterns of Streptococcus pyogenes and Staphylococcus aureus in the oropharynx of individuals with acne who were using or not using antibiotic therapy. DESIGN: A cross-sectional study. SETTING: The Dermatology Department of the Hospital of the University of Pennsylvania, Philadelphia. PATIENTS: Patients with acne. MAIN OUTCOME MEASURES: Presence or absence of S pyogenes and S aureus in the oropharynx as determined by culture and their resistance patterns to tetracycline antibiotics as determined by agar disk diffusion. RESULTS: Of 105 patients who participated, 42 were using oral or topical antibiotics and 63 patients were not using antibiotics. Six (10%) of those 63 not using any antibiotics had positive S pyogenes cultures compared with 13 (33%) of those successfully evaluated using antibiotics (n = 39) (prevalence risk ratio, 3.5; 95% confidence interval, 1.4-8.6; P=.003). A total of 85% of S pyogenes cultures (11/13) from those using antibiotics were resistant to at least 1 tetracycline antibiotic compared with 20% (1/5) from those not using antibiotics (P=.01). Of those not using antibiotics, 29% (18/62) had positive S aureus cultures compared with 22% (9/41) of those using antibiotics (prevalence risk ratio, 0.76; 95% confidence interval, 0.38-1.5; P=.42). No significant differences in resistance patterns of S aureus were found. CONCLUSIONS: Streptococcus pyogenes colonization and resistance in the oropharynx are associated with antibiotic therapy in patients with acne. The clinical and long-term effects of this finding need to be studied further.
OBJECTIVE: To estimate the prevalence and resistance patterns of Streptococcus pyogenes and Staphylococcus aureus in the oropharynx of individuals with acne who were using or not using antibiotic therapy. DESIGN: A cross-sectional study. SETTING: The Dermatology Department of the Hospital of the University of Pennsylvania, Philadelphia. PATIENTS: Patients with acne. MAIN OUTCOME MEASURES: Presence or absence of S pyogenes and S aureus in the oropharynx as determined by culture and their resistance patterns to tetracycline antibiotics as determined by agar disk diffusion. RESULTS: Of 105 patients who participated, 42 were using oral or topical antibiotics and 63 patients were not using antibiotics. Six (10%) of those 63 not using any antibiotics had positive S pyogenes cultures compared with 13 (33%) of those successfully evaluated using antibiotics (n = 39) (prevalence risk ratio, 3.5; 95% confidence interval, 1.4-8.6; P=.003). A total of 85% of S pyogenes cultures (11/13) from those using antibiotics were resistant to at least 1 tetracycline antibiotic compared with 20% (1/5) from those not using antibiotics (P=.01). Of those not using antibiotics, 29% (18/62) had positive S aureus cultures compared with 22% (9/41) of those using antibiotics (prevalence risk ratio, 0.76; 95% confidence interval, 0.38-1.5; P=.42). No significant differences in resistance patterns of S aureus were found. CONCLUSIONS:Streptococcus pyogenes colonization and resistance in the oropharynx are associated with antibiotic therapy in patients with acne. The clinical and long-term effects of this finding need to be studied further.
Authors: Lawrence F Eichenfield; Diane Thiboutot; Alan Shalita; Leonard Swinyer; Emil Tanghetti; Eduardo Tschen; Lisa Parr Journal: J Clin Aesthet Dermatol Date: 2009-11
Authors: James Q Del Rosso; Guy F Webster; Ted Rosen; Diane Thiboutot; James J Leyden; Richard Gallo; Clay Walker; George Zhanel; Lawrence Eichenfield Journal: J Clin Aesthet Dermatol Date: 2016-04-01
Authors: David J Margolis; Matthew Fanelli; Eli Kupperman; Maryte Papadopoulos; Joshua P Metlay; Sharon Xiangwen Xie; Joseph DiRienzo; Paul H Edelstein Journal: Arch Dermatol Date: 2011-11-21
Authors: Whitney P Bowe; Jennifer C Filip; Joseph M DiRienzo; Alla Volgina; David J Margolis Journal: J Drugs Dermatol Date: 2006-10 Impact factor: 2.114
Authors: Anna L Chien; Jerry Tsai; Sherry Leung; Emmanuel F Mongodin; Amanda M Nelson; Sewon Kang; Luis A Garza Journal: JAMA Dermatol Date: 2019-04-01 Impact factor: 10.282
Authors: John S Barbieri; Ketaki Bhate; Kathleen P Hartnett; Katherine E Fleming-Dutra; David J Margolis Journal: JAMA Dermatol Date: 2019-03-01 Impact factor: 10.282