Literature DB >> 1270703

Mechanism of decarboxylation of 1,3-dimethylorotic acid. A model for orotidine 5'-phosphate decarboxylase.

P Beak, B Siegel.   

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Year:  1976        PMID: 1270703     DOI: 10.1021/ja00428a035

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


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  21 in total

1.  Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase.

Authors:  N Wu; Y Mo; J Gao; E F Pai
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

2.  Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.

Authors:  B G Miller; A M Hassell; R Wolfenden; M V Milburn; S A Short
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

3.  The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.

Authors:  T C Appleby; C Kinsland; T P Begley; S E Ealick
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

4.  Convenient synthesis of N1-substituted orotic acid derivatives.

Authors:  Jeannette T Bowler; Caitlin R Clausen; Daniel J Blackburn; Weiming Wu
Journal:  Tetrahedron Lett       Date:  2014-11-19       Impact factor: 2.415

5.  Polarization in the structures of uracil and thiouracils: Implication for binding with orotidine 5'-monophosphate decarboxylase.

Authors:  Sha Huang; Scott Gronert; Weiming Wu
Journal:  Bioorg Med Chem Lett       Date:  2011-09-01       Impact factor: 2.823

6.  Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5'-monophosphate decarboxylase.

Authors:  Freeman M Wong; Christina C Capule; Weiming Wu
Journal:  Org Lett       Date:  2006-12-21       Impact factor: 6.005

7.  Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.

Authors:  Bogdana Goryanova; Lawrence M Goldman; Tina L Amyes; John A Gerlt; John P Richard
Journal:  Biochemistry       Date:  2013-10-08       Impact factor: 3.162

8.  The stability of aryl carbanions derived from pyridine N-oxide: the role of resonance in stabilizing aryl anions.

Authors:  Scott K Koehn; Ngoc L Tran; Scott Gronert; Weiming Wu
Journal:  J Am Chem Soc       Date:  2010-01-13       Impact factor: 15.419

9.  Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.

Authors:  Geoffrey R Nosrati; K N Houk
Journal:  Biochemistry       Date:  2012-08-30       Impact factor: 3.162

10.  QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.

Authors:  Courtney L Stanton; I-Feng W Kuo; Christopher J Mundy; Teodoro Laino; K N Houk
Journal:  J Phys Chem B       Date:  2007-10-10       Impact factor: 2.991

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