An unraveling tale of how integrins are activated from within.

Integrin cytoplasmic tail domains are short, but are essential for normal receptor function because of their key role in relaying bidirectional signals across the plasma membrane. Although it is well established that the cytoplasmic tails both initiate signalling pathways inside the cell and control the transition of integrins from a resting to a ligand-binding competent state, until recently the structural basis of these changes has been unclear. In the past year, however, a series of structural studies has revealed certain features of cytoplasmic domain function, and in this review we focus on how these advances have enlightened our understanding of integrin tail structure and function.