| Literature DB >> 12706988 |
Klaus Aktories1, Gudula Schmidt.
Abstract
Various bacterial protein toxins and effectors target Rho GTPases, which are eukaryotic regulators of signal transduction pathways. Many toxins inactivate these GTPases but some, such as the cytotoxic necrotizing factors (CNFs) from Escherichia coli, activate them by deamidation. Recent studies have provided exciting new clues to the functional consequences of the activation of Rho GTPases by CNFs and its effect on the host-pathogen interaction.Entities:
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Year: 2003 PMID： 12706988 DOI： 10.1016/s0966-842x(03)00042-8
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079