Literature DB >> 12706820

Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes.

Tatsuhiro Masaoka1, Hidekazu Suzuki, Hiroshi Hosoda, Takayuki Ota, Yuriko Minegishi, Hiroshi Nagata, Kenji Kangawa, Hiromasa Ishii.   

Abstract

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.

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Year:  2003        PMID： 12706820     DOI： 10.1016/s0014-5793(03)00306-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  22 in total

1.  Enhanced gastric ghrelin production and secretion in rats with gastric outlet obstruction.

Authors:  Eisuke Iwasaki; Hidekazu Suzuki; Tatsuhiro Masaoka; Toshihiro Nishizawa; Hiroshi Hosoda; Kenji Kangawa; Toshifumi Hibi
Journal:  Dig Dis Sci       Date:  2011-11-04       Impact factor: 3.199

2.  Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-/-) mice.

Authors:  Yuka Abiko; Hidekazu Suzuki; Tatsuhiro Masaoka; Sachiko Nomura; Kumiko Kurabayashi; Hiroshi Hosoda; Kenji Kangawa; Toshifumi Hibi
Journal:  World J Gastroenterol       Date:  2005-07-21       Impact factor: 5.742

3.  Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia.

Authors:  Kripa Shankar; Deepali Gupta; Bharath K Mani; Brianna G Findley; Caleb C Lord; Sherri Osborne-Lawrence; Nathan P Metzger; Claudio Pietra; Chen Liu; Eric D Berglund; Jeffrey M Zigman
Journal:  Diabetes       Date:  2019-11-04       Impact factor: 9.461

Review 4.  Ghrelin's second life: from appetite stimulator to glucose regulator.

Authors:  Pieter-Jan Verhulst; Inge Depoortere
Journal:  World J Gastroenterol       Date:  2012-07-07       Impact factor: 5.742

5.  Enhanced ghrelin expression and subsequent acid secretion in mice with genetic H(2)-receptor knockout.

Authors:  Mamoru Arakawa; Hidekazu Suzuki; Yuriko Minegishi; Yasushi Fukushima; Tatsuhiro Masaoka; Takashi Ishikawa; Hiroshi Hosoda; Kenji Kangawa; Toshifumi Hibi
Journal:  J Gastroenterol       Date:  2007-09-25       Impact factor: 7.527

6.  Post-prandial decrease of human plasma ghrelin in the absence of insulin.

Authors:  J Spranger; M Ristow; B Otto; W Heldwein; M Tschöp; A F H Pfeiffer; M Möhlig
Journal:  J Endocrinol Invest       Date:  2003-08       Impact factor: 4.256

7.  Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists.

Authors:  Anna-Sophia Wisser; Piet Habbel; Bertram Wiedenmann; Burghard F Klapp; Hubert Mönnikes; Peter Kobelt
Journal:  Int J Pept       Date:  2010-01-06

8.  Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils.

Authors:  H Suzuki; T Masaoka; H Hosoda; T Ota; Y Minegishi; S Nomura; K Kangawa; H Ishii
Journal:  Gut       Date:  2004-02       Impact factor: 23.059

9.  Ghrelin improves growth hormone responses to growth hormone-releasing hormone in a streptozotocin-diabetic model of delayed onset.

Authors:  Y Diz-Chaves; C Spuch; D Pérez; F Mallo
Journal:  J Endocrinol Invest       Date:  2007-04       Impact factor: 4.256

10.  The effect of zinc supplementation on ghrelin-immunoreactive cells and lipid parameters in gastrointestinal tissue of streptozotocin-induced female diabetic rats.

Authors:  S Bolkent; R Yanardag; S Bolkent; O Mutlu; S Yildirim; K Kangawa; Y Minegishi; H Suzuki
Journal:  Mol Cell Biochem       Date:  2006-02-15       Impact factor: 3.396
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