Literature DB >> 12706797

Characterization of PfRhop148, a novel rhoptry protein of Plasmodium falciparum.

Cheryl-Ann Lobo1, Marilis Rodriguez, Guangpei Hou, Margaret Perkins, Yelena Oskov, Sara Lustigman.   

Abstract

Rhoptries are apical organelles which play an important role in erythrocytic invasion. A Plasmodium falciparum cDNA clone, coding for a novel rhoptry protein PfRhop148, was obtained by antibody screening of a library. The deduced amino acid sequence consists of 1262 amino acids and is highly rich in Asn (22%). The Asn residues are distributed in clusters and in multiple units of repeats. Analysis of specific RNA transcript and protein showed that PfRhop148 was synthesized at around 21 h post-invasion. IFA and immunoelectron microscopic analyses revealed a rhoptry localization for the protein. The role of this protein in invasion and its relationship to the RhopH complex is now under further investigation.

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Year:  2003        PMID： 12706797     DOI： 10.1016/s0166-6851(03)00050-1

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  6 in total

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Authors:  Olivia L McGovern; Yolanda Rivera-Cuevas; Geetha Kannan; Andrew J Narwold; Vern B Carruthers
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2.  Characterisation of PfRON6, a Plasmodium falciparum rhoptry neck protein with a novel cysteine-rich domain.

Authors:  Nicholas I Proellocks; Lev M Kats; David A Sheffield; Eric Hanssen; Casilda G Black; Karena L Waller; Ross L Coppel
Journal:  Int J Parasitol       Date:  2008-11-27       Impact factor: 3.981

3.  Plasmodium falciparum Pf34, a novel GPI-anchored rhoptry protein found in detergent-resistant microdomains.

Authors:  Nicholas I Proellocks; Svetozar Kovacevic; David J P Ferguson; Lev M Kats; Belinda J Morahan; Casilda G Black; Karena L Waller; Ross L Coppel
Journal:  Int J Parasitol       Date:  2007-04-19       Impact factor: 3.981

4.  Evidence that the Malaria Parasite Plasmodium falciparum Putative Rhoptry Protein 2 Localizes to the Golgi Apparatus throughout the Erythrocytic Cycle.

Authors:  Stéphanie Hallée; Dave Richard
Journal:  PLoS One       Date:  2015-09-16       Impact factor: 3.240

5.  A malaria vaccine candidate based on an epitope of the Plasmodium falciparum RH5 protein.

Authors:  Rosalynn L Ord; Jerri C Caldeira; Marilis Rodriguez; Amy Noe; Bryce Chackerian; David S Peabody; Gabriel Gutierrez; Cheryl A Lobo
Journal:  Malar J       Date:  2014-08-18       Impact factor: 2.979

6.  PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor.

Authors:  Marilis Rodriguez; Sara Lustigman; Estrella Montero; Yelena Oksov; Cheryl A Lobo
Journal:  PLoS One       Date:  2008-10-01       Impact factor: 3.240
  6 in total

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