Histamine, part of the metabolome.

Histamine, a decarboxylated amino acid with a molecular mass of 112 daltons reveals multicoloured functional activities. Its role in allergy and inflammation is abundantly characterized. Moreover histamine is one of the neuotransmitters, has a role in gastric acid production and in maintenance of blood-brain barrier. In the last decade, many data were collected suggesting an important function of histamine in events of immune response and also in both benign and malignant cell proliferation. Our group collected data on the relevance of histamine as an autocrine factor in human melanoma. The outcome of the action seems to be closely related to the local and actual balance of histamine receptors (H1R, H2R, H3R and H4R) on tumor cells. Recently, using a gene targeted mouse strain (lacking an enzyme, histidine decarboxylase, the only one responsible for histamine production) many phenotype of the histamine-free mice were demonstrated. Our data suggest, that histamine, as part of the poorly characterized metabolome of the mammalian cells plays significant role in many physiological and pathological processes.