Literature DB >> 12704181

Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid.

S Häussler1, M Rohde, N von Neuhoff, M Nimtz, I Steinmetz.   

Abstract

In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.

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Year:  2003        PMID: 12704181      PMCID: PMC153222          DOI: 10.1128/IAI.71.5.2970-2975.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  23 in total

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Review 9.  Phagocytosis and the actin cytoskeleton.

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  14 in total

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Review 4.  Rhamnolipids: diversity of structures, microbial origins and roles.

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9.  Burkholderia thailandensis harbors two identical rhl gene clusters responsible for the biosynthesis of rhamnolipids.

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10.  Polar lipids of Burkholderia pseudomallei induce different host immune responses.

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