Literature DB >> 12703773

First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination.

T P Nicholson1, C Winfield, J Westcott, J Crosby, T J Simpson, R J Cox.   

Abstract

The minimal actinorhodin polyketide synthase bearing two point mutations (KSbeta Q161A, ACP C17S) was chemically modified to carry novel C4 to C8 starter units on the ACP: on incubation with an excess of malonyl CoA new 16-carbon polyketides are made, supporting a measuring mechanism.

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Year:  2003        PMID： 12703773     DOI： 10.1039/b300847a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters.

Authors:  Maureen E Hillenmeyer; Gergana A Vandova; Erin E Berlew; Louise K Charkoudian
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-23       Impact factor: 11.205

2.  Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase.

Authors:  Ping-Hui Szu; Sridhar Govindarajan; Michael J Meehan; Abhirup Das; Don D Nguyen; Pieter C Dorrestein; Jeremy Minshull; Chaitan Khosla
Journal:  Chem Biol       Date:  2011-08-26

3.  Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis.

Authors:  Abhirup Das; Ping-Hui Szu; Jay T Fitzgerald; Chaitan Khosla
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

4.  Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism.

Authors:  Miho Izumikawa; Qian Cheng; Bradley S Moore
Journal:  J Am Chem Soc       Date:  2006-02-08       Impact factor: 15.419

Review 5.  Biosynthesis of aromatic polyketides in bacteria.

Authors:  Abhirup Das; Chaitan Khosla
Journal:  Acc Chem Res       Date:  2009-05-19       Impact factor: 22.384

6.  Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases.

Authors:  Chen Wang; Xiaojing Wang; Liwen Zhang; Qun Yue; Qingpei Liu; Ya-Ming Xu; A A Leslie Gunatilaka; Xiaoyi Wei; Yuquan Xu; István Molnár
Journal:  J Am Chem Soc       Date:  2020-09-23       Impact factor: 15.419

7.  In vivo and in vitro analysis of the hedamycin polyketide synthase.

Authors:  Abhirup Das; Chaitan Khosla
Journal:  Chem Biol       Date:  2009-11-25

8.  A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.

Authors:  Meng Wang; Hui Zhou; Monica Wirz; Yi Tang; Christopher N Boddy
Journal:  Biochemistry       Date:  2009-07-14       Impact factor: 3.162

9.  Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.

Authors:  Tyler Paz Korman; Jason Anthony Hill; Thanh Nhat Vu; Shiou-Chuan Tsai
Journal:  Biochemistry       Date:  2004-11-23       Impact factor: 3.162

10.  Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases.

Authors:  Ting Liu; James F Sanchez; Yi-Ming Chiang; Berl R Oakley; Clay C C Wang
Journal:  Org Lett       Date:  2014-03-05       Impact factor: 6.005
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