Literature DB >> 12702697

Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein.

Eric A Gaucher1, Michael M Miyamoto, Steven A Benner.   

Abstract

The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.

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Year:  2003        PMID： 12702697      PMCID： PMC1462526     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  16 in total

1.  The chicken leptin gene: has it been cloned?

Authors:  M Friedman-Einat; T Boswell; G Horev; G Girishvarma; I C Dunn; R T Talbot; P J Sharp
Journal:  Gen Comp Endocrinol       Date:  1999-09       Impact factor: 2.822

Review 2.  Planetary biology--paleontological, geological, and molecular histories of life.

Authors:  Steven A Benner; M Daniel Caraco; J Michael Thomson; Eric A Gaucher
Journal:  Science       Date:  2002-05-03       Impact factor: 47.728

3.  Epitope mapping of secreted mouse leptin utilizing peripherally administered synthetic peptides.

Authors:  P Grasso; M C Leinung; D W Lee
Journal:  Regul Pept       Date:  1999-12-23

Review 4.  Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein kinases.

Authors:  S A Benner; D Gerloff
Journal:  Adv Enzyme Regul       Date:  1991

5.  Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor.

Authors:  P Grasso; D W White; L A Tartaglia; M C Leinung; D W Lee
Journal:  Diabetes       Date:  1999-11       Impact factor: 9.461

6.  Crystal structure of the obese protein leptin-E100.

Authors:  F Zhang; M B Basinski; J M Beals; S L Briggs; L M Churgay; D K Clawson; R D DiMarchi; T C Furman; J E Hale; H M Hsiung; B E Schoner; D P Smith; X Y Zhang; J P Wery; R W Schevitz
Journal:  Nature       Date:  1997-05-08       Impact factor: 49.962

7.  Molecular evolution of leptin.

Authors:  C Doyon; G Drouin; V L Trudeau; T W Moon
Journal:  Gen Comp Endocrinol       Date:  2001-11       Impact factor: 2.822

8.  Positional cloning of the mouse obese gene and its human homologue.

Authors:  Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal:  Nature       Date:  1994-12-01       Impact factor: 49.962

9.  A human leptin mutant induces weight gain in normal mice.

Authors:  S A Verploegen; G Plaetinck; R Devos; J Van der Heyden; Y Guisez
Journal:  FEBS Lett       Date:  1997-03-24       Impact factor: 4.124

10.  Statistical methods for detecting molecular adaptation.

Authors: 
Journal:  Trends Ecol Evol       Date:  2000-12-01       Impact factor: 17.712
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  16 in total

Review 1.  Selection on protein structure, interaction, and sequence.

Authors:  Peter B Chi; David A Liberles
Journal:  Protein Sci       Date:  2016-02-11       Impact factor: 6.725

2.  Tertiary windowing to detect positive diversifying selection.

Authors:  Ann-Charlotte Berglund; Björn Wallner; Arne Elofsson; David A Liberles
Journal:  J Mol Evol       Date:  2005-04       Impact factor: 2.395

3.  Exploiting models of molecular evolution to efficiently direct protein engineering.

Authors:  Megan F Cole; Eric A Gaucher
Journal:  J Mol Evol       Date:  2010-12-04       Impact factor: 2.395

4.  Leptin Concentrations in Non-Obese and Obese Non-Diabetes Nigerian-Africans.

Authors:  Obiageli Uzoamaka Agbogu-Ike; Dimie Ogoina; Geoffrey Chukwubuike Onyemelukwe
Journal:  Diabetes Metab Syndr Obes       Date:  2021-12-21       Impact factor: 3.168

5.  Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss.

Authors:  Robert N Trotter-Mayo; Margo R Roberts
Journal:  Endocrinology       Date:  2008-06-26       Impact factor: 4.736

6.  Evidence for positive selection on the leptin gene in Cetacea and Pinnipedia.

Authors:  Li Yu; Wei Jin; Xin Zhang; Ding Wang; Jin-song Zheng; Guang Yang; Shi-xia Xu; Soochin Cho; Ya-ping Zhang
Journal:  PLoS One       Date:  2011-10-27       Impact factor: 3.240

7.  Adaptive evolution of Leptin in heterothermic bats.

Authors:  Lihong Yuan; Xudong Zhao; Benfu Lin; Stephen J Rossiter; Lingjiang He; Xueguo Zuo; Guimei He; Gareth Jones; Fritz Geiser; Shuyi Zhang
Journal:  PLoS One       Date:  2011-11-16       Impact factor: 3.240

8.  Agrarian diet and diseases of affluence--do evolutionary novel dietary lectins cause leptin resistance?

Authors:  Tommy Jönsson; Stefan Olsson; Bo Ahrén; Thorkild C Bøg-Hansen; Anita Dole; Staffan Lindeberg
Journal:  BMC Endocr Disord       Date:  2005-12-10       Impact factor: 2.763

Review 9.  The role of leptin in innate and adaptive immune responses.

Authors:  Eiva Bernotiene; Gaby Palmer; Cem Gabay
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156

10.  Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics.

Authors:  Tang Li; Stephen G Chamberlin; M Daniel Caraco; David A Liberles; Eric A Gaucher; Steven A Benner
Journal:  BMC Evol Biol       Date:  2006-03-20       Impact factor: 3.260
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