Literature DB >> 12702154

The developing heart and congenital heart defects: a make or break situation.

B G Bruneau1.   

Abstract

Congenital heart defects are common in humans, but the underlying basis for these defects is not well understood. It has been clear that abnormal heart development is at the root of these diseases, but the genes involved have remained elusive until recently. This review focuses on recent advances in our understanding of mammalian heart formation, and how some of these processes, when disrupted, lead to congenital heart defects.

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Year:  2003        PMID: 12702154     DOI: 10.1034/j.1399-0004.2003.00066.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN: 0009-9163            Impact factor:   4.438


  14 in total

1.  Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.

Authors:  Ke K Zhang; Menglan Xiang; Lun Zhou; Jielin Liu; Nathan Curry; Damian Heine Suñer; Pablo Garcia-Pavia; Xiaohua Zhang; Qin Wang; Linglin Xie
Journal:  Hum Mol Genet       Date:  2016-01-06       Impact factor: 6.150

Review 2.  Quantifying blood flow dynamics during cardiac development: demystifying computational methods.

Authors:  Katherine Courchaine; Sandra Rugonyi
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-09-24       Impact factor: 6.237

3.  Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium.

Authors:  Ingeborg Friehs; Douglas B Cowan; Yeong-Hoon Choi; Kendra M Black; Reanne Barnett; Manoj K Bhasin; Christian Daly; Simon J Dillon; Towia A Libermann; Francis X McGowan; Pedro J del Nido; Sidney Levitsky; James D McCully
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-12-21       Impact factor: 4.733

4.  Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.

Authors:  Linglin Xie; Andrew D Hoffmann; Ozanna Burnicka-Turek; Joshua M Friedland-Little; Ke Zhang; Ivan P Moskowitz
Journal:  Dev Cell       Date:  2012-08-14       Impact factor: 12.270

5.  Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.

Authors:  Lun Zhou; Jielin Liu; Menglan Xiang; Patrick Olson; Alexander Guzzetta; Ke Zhang; Ivan P Moskowitz; Linglin Xie
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-06       Impact factor: 11.205

6.  Maternal periconceptional alcohol consumption and congenital heart defects.

Authors:  Yong Zhu; Paul A Romitti; Kristin M Caspers Conway; Dereck H Shen; Lixian Sun; Marilyn L Browne; Lorenzo D Botto; Angela E Lin; Charlotte M Druschel
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2015-06-27

7.  Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin.

Authors:  Jim Jung-Ching Lin; Elisabeth A Gustafson-Wagner; Haley W Sinn; Sunju Choi; Shannon M Jaacks; Da-Zhi Wang; Sylvia Evans; Jenny Li-Chun Lin
Journal:  J Med Sci       Date:  2005-10

8.  Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.

Authors:  Lun Zhou; Jielin Liu; Patrick Olson; Ke Zhang; Joshua Wynne; Linglin Xie
Journal:  J Mol Cell Cardiol       Date:  2015-05-16       Impact factor: 5.000

9.  Genetic counseling throughout the life cycle.

Authors:  Leslie J Ciarleglio; Robin L Bennett; Jennifer Williamson; Jessica B Mandell; Joan H Marks
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

Review 10.  Signaling and transcriptional networks in heart development and regeneration.

Authors:  Benoit G Bruneau
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-03-01       Impact factor: 10.005

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