O Avci1, S Caliskan, M Caliskan. 1. Department of Dermatology, School of Medicine, Dokuz Eylül University, Izmir, Turkey. oktay.avci@deu.edu.tr
Abstract
BACKGROUND: We have observed that the erythema in subjects with psoriasis vulgaris associated with non-insulin-dependent diabetes mellitus (NIDDM) presents a mostly deep-red to purple hue instead of the typical pink to red tones. We carried out a descriptive clinical study, including 141 patients with psoriasis vulgaris to quantify these colour differences. METHODS: Mean erythema index values were established for the psoriatic plaques of adult subjects using an optoelectronic method. Non-diabetic psoriatics underwent an oral glucose tolerance test (OGTT), and based on the results of the oral OGTTs, the subjects were divided into three groups: 18 psoriatics with NIDDM, 16 psoriatics with impaired glucose tolerance (IGT) and 107 psoriatics with normal glucose tolerance. The mean erythema index value was calculated for each group and the findings were compared. RESULTS: The differences in the erythema were found to be highly significant between the group of subjects with psoriasis having normal glucose tolerance and both those with IGT and those with NIDDM (P < 0.01 and P < 0.01). The differences in the erythema were also highly significant between the psoriatic group with normal glucose tolerance and the group of 34 psoriatics with IGT and NIDDM all together (P < 0.01). CONCLUSIONS: Individuation of the various hues of erythema in psoriatics by careful dermatological examination or routine measurements of lesional erythema may alert the physician to possible IGT in the presenting subject, and this may affect disease severity.
BACKGROUND: We have observed that the erythema in subjects with psoriasis vulgaris associated with non-insulin-dependent diabetes mellitus (NIDDM) presents a mostly deep-red to purple hue instead of the typical pink to red tones. We carried out a descriptive clinical study, including 141 patients with psoriasis vulgaris to quantify these colour differences. METHODS: Mean erythema index values were established for the psoriatic plaques of adult subjects using an optoelectronic method. Non-diabetic psoriatics underwent an oral glucose tolerance test (OGTT), and based on the results of the oral OGTTs, the subjects were divided into three groups: 18 psoriatics with NIDDM, 16 psoriatics with impaired glucose tolerance (IGT) and 107 psoriatics with normal glucose tolerance. The mean erythema index value was calculated for each group and the findings were compared. RESULTS: The differences in the erythema were found to be highly significant between the group of subjects with psoriasis having normal glucose tolerance and both those with IGT and those with NIDDM (P < 0.01 and P < 0.01). The differences in the erythema were also highly significant between the psoriatic group with normal glucose tolerance and the group of 34 psoriatics with IGT and NIDDM all together (P < 0.01). CONCLUSIONS: Individuation of the various hues of erythema in psoriatics by careful dermatological examination or routine measurements of lesional erythema may alert the physician to possible IGT in the presenting subject, and this may affect disease severity.