| Literature DB >> 1270160 |
Abstract
The immunological release of slow-reacting substance of anaphylaxis (SRS-A) from bovine lung is modulated by several autonomic and autacoid agents. Isoproterenol, a beta-adrenergic agonist, inhibited release of SRS-A, as did cyclic AMP. Phenylephrine also inhibited SRS-A release but through alpha-adrenergic mechanisms. This is in contrast to observations in human lung. Carbachol enhanced the release of bovine SRS-A. Histamine inhibited SRS-A release through the H2-receptor. Dopamine enhanced the release of SRS-A by means of a dopaminergic receptor. 5-HT did not significantly modulate SRS-A release.Entities:
Mesh：
Substances：
Year: 1976 PMID： 1270160 DOI： 10.1159/000231545
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915