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Literature DB >> 12700949

Immunotoxins containing Pseudomonas exotoxin A: a short history.

Ira Pastan¹.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12700949 DOI： 10.1007/s00262-002-0353-8

Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.630

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19 in total

1. The antimelanoma immunocytokine scFvMEL/TNF shows reduced toxicity and potent antitumor activity against human tumor xenografts.

Authors: Yuying Liu; Weihe Zhang; Lawrence H Cheung; Ting Niu; Qingping Wu; Chun Li; Carolyn S Van Pelt; Michael G Rosenblum
Journal: Neoplasia Date: 2006-05 Impact factor: 5.715

Review 2. Novel bacterial ADP-ribosylating toxins: structure and function.

Authors: Nathan C Simon; Klaus Aktories; Joseph T Barbieri
Journal: Nat Rev Microbiol Date: 2014-07-14 Impact factor: 60.633

3. Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia.

Authors: Francis Mussai; Dario Campana; Deepa Bhojwani; Maryalice Stetler-Stevenson; Seth M Steinberg; Alan S Wayne; Ira Pastan
Journal: Br J Haematol Date: 2010-06-07 Impact factor: 6.998

4. Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial.

Authors: Alan S Wayne; Robert J Kreitman; Harry W Findley; Glen Lew; Cynthia Delbrook; Seth M Steinberg; Maryalice Stetler-Stevenson; David J Fitzgerald; Ira Pastan
Journal: Clin Cancer Res Date: 2010-03-09 Impact factor: 12.531

5. In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin.

Authors: Xikun Zhou; Ji Qiu; Zhen Wang; Nongyu Huang; Xiaolei Li; Qian Li; Yinbing Zhang; Chengjian Zhao; Can Luo; Nannan Zhang; Xiu Teng; Zhongwen Chen; Xiao Liu; Xianlian Yu; Wenling Wu; Yu-quan Wei; Jiong Li
Journal: J Cancer Res Clin Oncol Date: 2012-03-07 Impact factor: 4.553

Immunotoxins containing Pseudomonas exotoxin A: a short history.

1. The antimelanoma immunocytokine scFvMEL/TNF shows reduced toxicity and potent antitumor activity against human tumor xenografts.

Review 2. Novel bacterial ADP-ribosylating toxins: structure and function.

3. Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia.

4. Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial.

5. In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin.

Review 6. Strategies to Reduce the Immunogenicity of Recombinant Immunotoxins.

7. Isolation of anti-CD22 Fv with high affinity by Fv display on human cells.

8. In vitro and in vivo antitumor effects of the recombinant immunotoxin IL6(T23)-PE38KDEL in multiple myeloma.

9. An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo.

10. EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.