Literature DB >> 12700125

BRCA proteins and DNA damage checkpoints.

Zhenkun Lou1, Junjie Chen.   

Abstract

BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage

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Year:  2003        PMID： 12700125     DOI： 10.2741/1127

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  2 in total

1.  Students investigating the antiproliferative effects of synthesized drugs on mouse mammary tumor cells.

Authors:  Rasha Hammamieh; Margery Anderson; Katharine Carr; Christine N Tran; Debra L Yourick; Marti Jett
Journal:  Cell Biol Educ       Date:  2005

2.  Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

Authors:  Erik S Zimmerman; Junjie Chen; Joshua L Andersen; Orly Ardon; Jason L Dehart; Jana Blackett; Shailesh K Choudhary; David Camerini; Paul Nghiem; Vicente Planelles
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272
  2 in total

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