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Literature DB >> 12700086

Function of bone morphogenetic protein signaling during mouse development.

Abstract

Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

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Year: 2003 PMID： 12700086 DOI： 10.2741/1097

Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715

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Cited

26 in total

1. Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo.

Authors: Shigeto Miura; Yuji Mishina
Journal: Dev Dyn Date: 2011-09-26 Impact factor: 3.780

2. BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis.

Authors: Yoshihiro Komatsu; Gregory Scott; Andre Nagy; Vesa Kaartinen; Yuji Mishina
Journal: Dev Dyn Date: 2007-02 Impact factor: 3.780

3. Developmental signaling in myocardial progenitor cells: a comprehensive view of Bmp- and Wnt/beta-catenin signaling.

Authors: Alexandra Klaus; Walter Birchmeier
Journal: Pediatr Cardiol Date: 2008-12-20 Impact factor: 1.655

4. Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis.

Authors: Yina Li; Julie Gordon; Nancy R Manley; Ying Litingtung; Chin Chiang
Journal: Dev Biol Date: 2008-07-26 Impact factor: 3.582

5. Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina.

Authors: Deepa Murali; Motoko Kawaguchi-Niida; Chu-Xia Deng; Yasuhide Furuta
Journal: Invest Ophthalmol Vis Sci Date: 2011-05-02 Impact factor: 4.799

Function of bone morphogenetic protein signaling during mouse development.

1. Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo.

2. BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis.

3. Developmental signaling in myocardial progenitor cells: a comprehensive view of Bmp- and Wnt/beta-catenin signaling.

4. Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis.

5. Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina.

Review 6. New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.

7. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.

8. Nuclear variants of bone morphogenetic proteins.

9. Bmp2 is required for cephalic neural tube closure in the mouse.

10. Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression.