| Literature DB >> 12699823 |
Marília O F Goulart1, Piotr Falkowski, Tadeusz Ossowski, Adam Liwo.
Abstract
Cyclovoltammetric studies were performed with lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone], in the absence and presence of oxygen, which aimed to investigate possible oxygen interaction with lapachol and its radical anion. The obtained results clearly indicate the consumption of the semiquinone anion-radicals by oxygen in an EC type reaction, generating the deprotonated form of lapachol and HOO*. The observed generation of reactive oxygen species (ROS) after electron transfer can be related to the mechanism of biological action of lapachol.Entities:
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Year: 2003 PMID： 12699823 DOI： 10.1016/s1567-5394(03)00005-7
Source DB: PubMed Journal: Bioelectrochemistry ISSN： 1567-5394 Impact factor: 5.373