Literature DB >> 1269980

Effects of aspirin on gastric prostaglandin E (PGE) and acid output in normal subjects.

C Child, W Jubiz, J G Moore.   

Abstract

Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibition by aspirin at 11 p.m., midnight, and 1am was observed.

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Year:  1976        PMID： 1269980      PMCID： PMC1411058          DOI： 10.1136/gut.17.1.54

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  11 in total

Review 1.  Prostaglandins: their actions on the gastrointestinal tract.

Authors:  D E Wilson
Journal:  Arch Intern Med       Date:  1974-01

2.  Physiologic role of prostaglandins of the E(PGE), F(PGF) and AB(PGAB) groups. Estimation by radioimmunoassay in unextracted human plasma.

Authors:  W Jubiz; J Frailey; C Child; K Bartholomew
Journal:  Prostaglandins       Date:  1972-12

3.  Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds.

Authors:  C Pace-Asciak
Journal:  Biochim Biophys Acta       Date:  1972-09-07

4.  The effect of prostaglandin E 1 on the pentagastrin-stimulated gastric secretion in man.

Authors:  M Classen; H Koch; J Bickhardt; G Topf; L Demling
Journal:  Digestion       Date:  1971       Impact factor: 3.216

5.  Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat.

Authors:  A Robert; J E Nezamis; J P Phillips
Journal:  Gastroenterology       Date:  1968-10       Impact factor: 22.682

6.  Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man.

Authors:  E W Horton; I H Main; C J Thompson; P M Wright
Journal:  Gut       Date:  1968-12       Impact factor: 23.059

7.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

8.  Circadian variation of prostaglandin E(PGE) production in human gastric juice.

Authors:  M G Tonnesen; W Jubiz; J G Moore; J Frailey
Journal:  Am J Dig Dis       Date:  1974-07

9.  Prostaglandin E2 and gastric acid secretion in man.

Authors:  A Bennett; I F Stamford; W G Unger
Journal:  J Physiol       Date:  1973-03       Impact factor: 5.182

10.  Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ).

Authors:  A Robert; D F Stowe; J E Nezamis
Journal:  Scand J Gastroenterol       Date:  1971       Impact factor: 2.423
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  3 in total

1.  Effect of the prostaglandin precursor, arachidonic acid, on histamine stimulated gastric secretion in the conscious dog, and observations on the effect of inhibiting endogenous prostaglandin synthesis.

Authors:  M E Conolly; P R Bieck; N A Payne; B Adkins; J A Oates
Journal:  Gut       Date:  1977-06       Impact factor: 23.059

2.  Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion.

Authors:  J N Hunt; J L Smith; C L Jiang; L Kessler
Journal:  Dig Dis Sci       Date:  1983-10       Impact factor: 3.199

3.  The pathogenesis of the aspirin-related gastric lesion.

Authors:  J M Duggan
Journal:  J R Coll Physicians Lond       Date:  1981-04
  3 in total

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