Literature DB >> 12699759

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Jason Witherington1, Vincent Bordas, Stephen L Garland, Deirdre M B Hickey, Robert J Ife, John Liddle, Martin Saunders, David G Smith, Robert W Ward.   

Abstract

A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

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Year:  2003        PMID： 12699759     DOI： 10.1016/s0960-894x(03)00134-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

Authors:  Peng Zhang; Mu-Fa Zou; Alice L Rodriguez; P Jeffrey Conn; Amy Hauck Newman
Journal:  Bioorg Med Chem       Date:  2010-03-27       Impact factor: 3.641

2.  Construction of pyrazolo[3,4-b]pyridines and pyrazolo[4,3-c]pyridines by ring closure of 3-acylpyridine N-oxide tosylhydrazones.

Authors:  William J Lominac; Megan L D'Angelo; Mark D Smith; Darius A Ollison; James M Hanna
Journal:  Tetrahedron Lett       Date:  2012-02-22       Impact factor: 2.415

3.  Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.

Authors:  Sivaprakasam Prasanna; Pankaj R Daga; Aihua Xie; Robert J Doerksen
Journal:  J Comput Aided Mol Des       Date:  2008-10-07       Impact factor: 3.686

4.  Synthesis of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridines via one-pot sequential Suzuki-Miyaura coupling.

Authors:  Vibha Tandon; Parthasarathi Das; S Kukreti
Journal:  RSC Adv       Date:  2018-10-11       Impact factor: 3.361

5.  Four-component bicyclization approaches to skeletally diverse pyrazolo[3,4-b]pyridine derivatives.

Authors:  Xing-Jun Tu; Wen-Juan Hao; Qin Ye; Shuang-Shuang Wang; Bo Jiang; Guigen Li; Shu-Jiang Tu
Journal:  J Org Chem       Date:  2014-11-04       Impact factor: 4.354

6.  Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors.

Authors:  Daniela Hulcová; Kateřina Breiterová; Tomáš Siatka; Kamila Klímová; Lara Davani; Marcela Šafratová; Anna Hošťálková; Angela De Simone; Vincenza Andrisano; Lucie Cahlíková
Journal:  Molecules       Date:  2018-03-21       Impact factor: 4.411

Review 7.  1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications.

Authors:  Ana Donaire-Arias; Ana Maria Montagut; Raimon Puig de la Bellacasa; Roger Estrada-Tejedor; Jordi Teixidó; José I Borrell
Journal:  Molecules       Date:  2022-03-30       Impact factor: 4.411

8.  Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models.

Authors:  Thomas Kramer; Boris Schmidt; Fabio Lo Monte
Journal:  Int J Alzheimers Dis       Date:  2012-07-22

9.  Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.

Authors:  M Lourdes Sciú; Victor Sebastián-Pérez; Loreto Martinez-Gonzalez; Rocio Benitez; Daniel I Perez; Concepción Pérez; Nuria E Campillo; Ana Martinez; E Laura Moyano
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

10.  Crystal structure analysis of ethyl 3-(4-chloro-phen-yl)-1,6-dimethyl-4-methyl-sulfanyl-1H-pyrazolo[3,4-b]pyridine-5-carboxyl-ate.

Authors:  H Surya Prakash Rao; Ramalingam Gunasundari; Jayaraman Muthukumaran
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2020-02-25
  10 in total

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