| Literature DB >> 12699746 |
Akiyuki Hamasaki1, Hayato Naka, Fuyuhiko Tamanoi, Kazuo Umezawa, Masami Otsuka.
Abstract
A novel metal chelator comprising a 4-(naphthalen-1-yl)pyridine and 2-aminoethanethiol was synthesized. This showed inhibitory activity against human protein farnesyltransferase with IC(50) 1.9 microM, induced morphological change in K-ras-NRK cells at 0.5 microg/mL and showed growth inhibition of K-ras-NRK cells with IC(50) 0.32 microg/mL.Entities:
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Year: 2003 PMID： 12699746 DOI： 10.1016/s0960-894x(03)00183-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823