Developing bioactive composite materials for tissue replacement.

A variety of bioactive composites have been investigated over the last two decades as substitute materials for diseased or damaged tissues in the human body. In this paper, the rationale and strategy of developing these composites are given. Major factors influencing the production and performance of bioactive composites are discussed. Some promising composites for tissue replacement and regeneration are reviewed. On the basis of past experience and newly gained knowledge, composite materials with tailored mechanical and biological performance can be manufactured and used to meet various clinical requirements.