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Literature DB >> 1269847

Secretin and insulin: response to intraduodenal acid.

F A O'Connor, K D Buchanan, J J Connon, M Shahidullah.

Abstract

Immunoreactive secretin (IRS) and immunoreactive insulin (IRI) levels were measured in humans and dogs following the intraduodenal instillation of hydrochloric acid. IRS levels rose after acid in both instances, but a concomitant rise in peripheral IRI levels was not noted. Premedication of the humans with Scopolamine prevented a rise of IRS in the human subjects. It is concluded that the endovenous release of IRS alone does not result in increased IRI levels in peripheral blood and that IRS release may be under vagal control.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1976 PMID： 1269847 DOI： 10.1007/BF00428980

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

25 in total

1. INHIBITION OF THE SECRETIN MECHANISM BY LOCAL ANESTHETICS.

Authors: H SCHAPIRO; E R WOODWARD
Journal: Am Surg Date: 1965-02 Impact factor: 0.688

2. MECHANISM OF ACTION OF PANCREATIC STIMULI STUDIED BY MEANS OF ATROPINELIKE DRUGS.

Authors: J E THOMAS
Journal: Am J Physiol Date: 1964-01

3. Immunofluorescent localization of secretin in the canine duodenum.

Authors: J M Polak; S Bloom; I Coulling; A G Pearse
Journal: Gut Date: 1971-08 Impact factor: 23.059

4. Failure of endogenous stimulation of secretin and pancreozymin release to influence serum-insulin.

Authors: R J Mahler; H Weisberg
Journal: Lancet Date: 1968-03-02 Impact factor: 79.321

5. Potentiation of secretin stimulation of the pancreas.

Authors: J C Brown; A A Harper; T Scratcherd
Journal: J Physiol Date: 1967-06 Impact factor: 5.182

6. Antibodies to unconjugated synthetic and natural secretins.

Authors: K D Buchanan; J D Teale; G Harper
Journal: Horm Metab Res Date: 1972-11 Impact factor: 2.936

7. Intestinal hormones and plasma insulin: an insulinotropic action of secretin.

Authors: D R Boyns; R J Jarrett; H Keen
Journal: Br Med J Date: 1967-06-10

8. Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man.

Authors: J Dupre; J D Curtis; R H Unger; R W Waddell; J C Beck
Journal: J Clin Invest Date: 1969-04 Impact factor: 14.808

Secretin and insulin: response to intraduodenal acid.

1. INHIBITION OF THE SECRETIN MECHANISM BY LOCAL ANESTHETICS.

2. MECHANISM OF ACTION OF PANCREATIC STIMULI STUDIED BY MEANS OF ATROPINELIKE DRUGS.

3. Immunofluorescent localization of secretin in the canine duodenum.

4. Failure of endogenous stimulation of secretin and pancreozymin release to influence serum-insulin.

5. Potentiation of secretin stimulation of the pancreas.

6. Antibodies to unconjugated synthetic and natural secretins.

7. Intestinal hormones and plasma insulin: an insulinotropic action of secretin.

8. Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man.

9. The gastrointestinal stimulus to insulin release. I. Secretin.

10. The effects of secretin, pancreozymin, and gastrin on insulin and glucagon secretion in anesthetized dogs.

1. Role of neural influences in the release of gastrin, glucagon, and secretin during hypoglycaemia in man.

2. Secretion pattern of secretin in man: regulation by gastric acid.

3. Effect of secretin on basal- and glucose-stimulated insulin secretion in man.