| Literature DB >> 12698322 |
Abstract
In some cases, the slow rotational movement underlying peptide bond cis/trans isomerizations is found to control the biological activity of proteins. Peptide bond cis/trans isomerases as cyclophilins, Fk506-binding proteins, parvulins, and bacterial hsp70 generally assist in the interconversion of the polypeptide substrate cis/trans isomers, and rate acceleration is the dominating mechanism of action in cells. We present evidence disputing the hypothesis that some of the molecular properties of these proteins play an auxiliary role in enzyme function.Entities:
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Year: 2003 PMID： 12698322 DOI： 10.1007/s10254-003-0011-3
Source DB: PubMed Journal: Rev Physiol Biochem Pharmacol ISSN： 0303-4240 Impact factor: 5.545