Molecular characterization of the porcine gene CAPNS1 encoding the small subunit 1 of calpain on SSC6q1.1-->q1.2.

The CAPNS1 gene encodes the small subunit of the calpain proteases. Cloning and characterization of the porcine CAPNS1 gene revealed a highly conserved organization with respect to other mammalian CAPNS1 orthologs. The porcine gene consists of 11 exons spanning approximately 7.3 kb and codes for a peptide of 266 amino acids. Analysis of the naturally occurring variation of the CAPNS1 gene in different pig breeds revealed six SNPs and four small insertion/deletion polymorphisms. The CAPNS1 gene is located immediately adjacent to the COX7A1 gene on SSC6q1.1-->q1.2. Copyright 2002 S. Karger AG, Basel