| Literature DB >> 12697336 |
Juncheng Li1, Berthony Deslouches, Sharon D Cosloy, Charlotte Sananes Russell.
Abstract
The key regulatory step in heme biosynthesis in Escherichia coli is at the level of glutamyl-tRNA reductase (GTR), an enzyme which is encoded by hemA. A strain, HU227, with a spontaneous in-frame mutation in hemA has no GTR activity. The mutation is shown to be a three-base deletion at a "hotspot" in the gene. The amino acid sequence in this region is highly conserved.Entities:
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Year: 2003 PMID： 12697336 DOI： 10.1016/s0167-4781(03)00041-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002