Literature DB >> 1269612

Antitumor activity of the Isodon diterpenoids: structural requirements for the activity.

E Fujita, Y Nagao, M Node, K Kaneko, S Nakazawa, H Kuroda.   

Abstract

A significant antitumor activity of oridonin (1) and lasiokaurin (2), the kaurene-type diterpenoids of Isodon species, was shown by their i.p. injection to the test mice inoculated by Ehrlich ascites carcinoma. Enmein (8), compounds 9 and 3 were also active under larger dose. Subsequently, the relationship between their chemical structure and antitumor activity was investigated, and the activity of oridonin (1) and lasiokaurin (2) was rationalized in terms of their structural feature.

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Year:  1976        PMID： 1269612     DOI： 10.1007/BF01937766

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Antitumor activity of the components of Isodon trichocarpus and related plants.

Authors:  T ARAI; Y KOYAMA; T SUENAGA; T MORITA
Journal:  J Antibiot (Tokyo)       Date:  1963-05       Impact factor: 2.649

2.  Sarkomycin, and anti-cancer substance produced by Stroptomyces.

Authors:  H UMEZAWA; T YAMAMOTO; T TAKEUCHI; T OSATO; Y OKAMI; S YAMAOKA; T OKUDA; K NITTA; K YAGISHITA; R UTAHARA; S UMEZAWA
Journal:  Antibiot Chemother (Northfield)       Date:  1954-05

3.  The absolute configuration of sarkomycin.

Authors:  R K Hill; P J Foley; L A Gardella
Journal:  J Org Chem       Date:  1967-07       Impact factor: 4.354

4.  [Terpenoids. XXXL. Biogenetic classification of Isodon diterpenoids (author's transl)].

Authors:  E Fujita; M Node; Y Nagao; T Fujita
Journal:  Yakugaku Zasshi       Date:  1974-07       Impact factor: 0.302

5.  Recent advances in the chemistry of terpenoid tumor inhibitors.

Authors:  S M Kupchan
Journal:  Pure Appl Chem       Date:  1970       Impact factor: 2.453
  5 in total
  17 in total

1.  Effect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazole.

Authors:  C Murayama; Y Nagao; S Sano; M Ochiai; K Fuji; E Fujita; T Mori
Journal:  Experientia       Date:  1987-12-01

2.  Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.

Authors:  Guang-Biao Zhou; Hui Kang; Lan Wang; Li Gao; Ping Liu; Jun Xie; Feng-Xiang Zhang; Xiang-Qin Weng; Zhi-Xiang Shen; Jue Chen; Long-Jun Gu; Ming Yan; Dong-Er Zhang; Sai-Juan Chen; Zhen-Yi Wang; Zhu Chen
Journal:  Blood       Date:  2006-12-29       Impact factor: 22.113

Review 3.  Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin.

Authors:  Wei Tian; Si-Yu Chen
Journal:  Chin J Integr Med       Date:  2013-04-02       Impact factor: 1.978

4.  Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway.

Authors:  Yong Guo; Qingqing Shan; Yuping Gong; Juan Lin; Xi Yang; Ruiqing Zhou
Journal:  Cancer Biol Ther       Date:  2012-08-16       Impact factor: 4.742

5.  Anti-hepatoma activity of a novel compound glaucocalyxin H in vivo and in vitro.

Authors:  Guangfan Hai; Chong Zhang; Yanlong Jia; Suping Bai; Jinfen Han; Lanqing Guo; Taizhen Cui; Bingxuan Niu; Feng Huang; Yu Song
Journal:  AAPS PharmSciTech       Date:  2014-11-06       Impact factor: 3.246

Review 6.  Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents.

Authors:  X Zhang; L-X Chen; L Ouyang; Y Cheng; B Liu
Journal:  Cell Prolif       Date:  2012-07-06       Impact factor: 6.831

7.  Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells.

Authors:  Yue Li; Ying Wang; Suihai Wang; Yanjun Gao; Xuefeng Zhang; Chunhua Lu
Journal:  Med Oncol       Date:  2014-12-10       Impact factor: 3.064

8.  Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells.

Authors:  Zhe Ji; Qingjiu Tang; Jinsong Zhang; Yan Yang; Yanfang Liu; Yingjie Pan
Journal:  Oncol Lett       Date:  2011-09-02       Impact factor: 2.967

9.  Identification of rapid access to polycyclic systems via a base-catalyzed cascade cyclization reaction and their biological evaluation.

Authors:  Taotao Ling; Victor Hadi; John Bollinger; Fatima Rivas
Journal:  Bioorg Chem       Date:  2020-04-18       Impact factor: 5.275

10.  ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids.

Authors:  Chunyong Ding; Lili Wang; Haijun Chen; Christopher Wild; Na Ye; Ye Ding; Tianzhi Wang; Mark A White; Qiang Shen; Jia Zhou
Journal:  Org Biomol Chem       Date:  2014-11-14       Impact factor: 3.876
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