BACKGROUND AND PURPOSE: In the treatment of cerebral aneurysms, platinum coils often fail to elicit a fibrotic response. We tested the hypothesis that a new, collagen-based endovascular coil would improve angiographic and histologic outcomes as compared with those achieved with platinum coils in a rabbit model of saccular aneurysms. METHODS: Elastase-induced aneurysms were created in 12 New Zealand White rabbits (body weight, 3-4 kg). Embolization was performed either by use of collagen-based coils (n = 6) or platinum coils (n = 6). In both coil groups, subjects were kept alive for either 2 weeks (n = 3 [collagen], n = 3 [platinum]) or 10 weeks (n = 3 [collagen], n = 3 [platinum]) after embolization and then were sacrificed. Digital subtraction angiography (DSA) was performed immediately after embolization and immediately before sacrifice. Postmortem histologic analysis of all coils was performed. RESULTS: Collagen-based coils were loosely packed in all cases because of limitations in size of coils available for embolization. In all six aneurysms packed with collagen-based coils, progressive thrombosis was noted at follow-up (DSA). Platinum coil samples were densely packed in all six cases. Progressive thrombosis was seen in one case, and interval regrowth was present in one case. Two weeks after embolization, collagen-based coil samples showed a marked peri-coil cellular response. Ten weeks after embolization, collagen-based samples had dense connective tissue matrix deposition in two of three cases. Platinum coils had unorganized thrombus at 2 weeks; loose-matrix deposition was only seen in the 10-week samples. Smooth muscle actin-positive cells were seen across the neck of the aneurysm in four of six collagen-based coil cases. CONCLUSION: Collagen-based coils show a marked cellular response in animal-model aneurysms, with resultant high rates of progressive occlusion after embolization. Dense matrix deposition is commonly seen with collagen-based coils. This contrasts with low rates of progressive thrombosis and high rates of loose matrix deposition seen with platinum coils.
BACKGROUND AND PURPOSE: In the treatment of cerebral aneurysms, platinum coils often fail to elicit a fibrotic response. We tested the hypothesis that a new, collagen-based endovascular coil would improve angiographic and histologic outcomes as compared with those achieved with platinum coils in a rabbit model of saccular aneurysms. METHODS: Elastase-induced aneurysms were created in 12 New Zealand White rabbits (body weight, 3-4 kg). Embolization was performed either by use of collagen-based coils (n = 6) or platinum coils (n = 6). In both coil groups, subjects were kept alive for either 2 weeks (n = 3 [collagen], n = 3 [platinum]) or 10 weeks (n = 3 [collagen], n = 3 [platinum]) after embolization and then were sacrificed. Digital subtraction angiography (DSA) was performed immediately after embolization and immediately before sacrifice. Postmortem histologic analysis of all coils was performed. RESULTS: Collagen-based coils were loosely packed in all cases because of limitations in size of coils available for embolization. In all six aneurysms packed with collagen-based coils, progressive thrombosis was noted at follow-up (DSA). Platinum coil samples were densely packed in all six cases. Progressive thrombosis was seen in one case, and interval regrowth was present in one case. Two weeks after embolization, collagen-based coil samples showed a marked peri-coil cellular response. Ten weeks after embolization, collagen-based samples had dense connective tissue matrix deposition in two of three cases. Platinum coils had unorganized thrombus at 2 weeks; loose-matrix deposition was only seen in the 10-week samples. Smooth muscle actin-positive cells were seen across the neck of the aneurysm in four of six collagen-based coil cases. CONCLUSION: Collagen-based coils show a marked cellular response in animal-model aneurysms, with resultant high rates of progressive occlusion after embolization. Dense matrix deposition is commonly seen with collagen-based coils. This contrasts with low rates of progressive thrombosis and high rates of loose matrix deposition seen with platinum coils.
Authors: Y Murayama; F Viñuela; Y Suzuki; Y Akiba; A Ulihoa; G R Duckwiler; Y P Gobin; H V Vinters; M Iwaki; T Abe Journal: AJNR Am J Neuroradiol Date: 1999 Nov-Dec Impact factor: 3.825
Authors: I Szikora; A K Wakhloo; L R Guterman; T D Chavis; R C Dawson; R W Hergenrother; R H Twyford; L N Hopkins Journal: AJNR Am J Neuroradiol Date: 1997-04 Impact factor: 3.825
Authors: D F Kallmes; M K Borland; H J Cloft; T A Altes; J E Dion; M E Jensen; G R Hankins; G A Helm Journal: Radiology Date: 1998-01 Impact factor: 11.105
Authors: Y H Ding; D Dai; M A Danielson; R Kadirvel; D A Lewis; H J Cloft; D F Kallmes Journal: AJNR Am J Neuroradiol Date: 2006-09 Impact factor: 3.825
Authors: Y H Ding; D Dai; D A Lewis; M A Danielson; R Kadirvel; J N Mandrekar; H J Cloft; D F Kallmes Journal: AJNR Am J Neuroradiol Date: 2006-09 Impact factor: 3.825
Authors: Daying Dai; Yong Hong Ding; Mark A Danielson; Ramanathan Kadirvel; Debra A Lewis; Harry J Cloft; David F Kallmes Journal: AJNR Am J Neuroradiol Date: 2005 Nov-Dec Impact factor: 3.825
Authors: Y H Ding; D Dai; D A Lewis; M A Danielson; R Kadirvel; H J Cloft; D F Kallmes Journal: AJNR Am J Neuroradiol Date: 2006-01 Impact factor: 3.825