Methods for predicting chronic toxicity parameters of substances in the area of water hygiene.

The development of rapid methods for determining chronic toxicity parameters of chemical compounds introduced by the oral route into an organism with water was studied. Formulas are verified with which threshold values and no-effect toxicity doses for substances can be obtained on the basis of various toxicologic parameters. For the example of organophosphates, a methodological scheme was developed for conducting an accelerated experiment for predicting the chronic toxicity of low and average cumulative compounds. Results are presented indicating the inadvisability of using lower animals as test subjects with the aim of predicting toxicity for higher animals. It is pointed out that patterns of homology and isomerism are observed in the comparison of chronic intoxication threshold doses as well as in acute toxicity values of substances.