Eva López-Quesada1, M Antonia Vilaseca, Jose M Lailla. 1. Obstetrics and Gynecology Department, Hospital Sant Joan de Déu, University of Barcelona, 08950-Esplugues de Llobregat, Barcelona, Spain.
Abstract
OBJECTIVES: (a) To establish the reference values for plasma total homocysteine in our pregnant population. (b) To determine the possible association between hyperhomocysteinemia and preeclampsia in our geographical area. STUDY DESIGN: Control-case study with 32 preeclamptic patients and 64 controls without pregnancy complications. Plasma total homocysteine, determined by HPLC (fluorescence detection), was correlated with serum folate and Vitamin B(12) (analyzed by competitive protein binding chemiluminescent assay). STATISTICAL ANALYSES: Mann-Whitney, Wilcoxon and Spearman test (SPSS, 10.0). RESULTS: Homocysteine concentrations in the controls were significantly higher while folate was significantly lower in the third trimester of pregnancy when compared with the second (P<0.0001). Homocysteine and folate values were significantly higher in patients compared with controls in the third trimester (P=0.005 and 0.005, respectively). The OR for preeclampsia in hyperhomocysteinemia was 7.7 (95% CI: 1.7-34.8). CONCLUSION: Pregnant women with hyperhomocysteinemia have a 7.7-fold risk for preeclampsia (CI 95%: 1.7-34.8) compared with normal controls.
OBJECTIVES: (a) To establish the reference values for plasma total homocysteine in our pregnant population. (b) To determine the possible association between hyperhomocysteinemia and preeclampsia in our geographical area. STUDY DESIGN: Control-case study with 32 preeclamptic patients and 64 controls without pregnancy complications. Plasma total homocysteine, determined by HPLC (fluorescence detection), was correlated with serum folate and Vitamin B(12) (analyzed by competitive protein binding chemiluminescent assay). STATISTICAL ANALYSES: Mann-Whitney, Wilcoxon and Spearman test (SPSS, 10.0). RESULTS:Homocysteine concentrations in the controls were significantly higher while folate was significantly lower in the third trimester of pregnancy when compared with the second (P<0.0001). Homocysteine and folate values were significantly higher in patients compared with controls in the third trimester (P=0.005 and 0.005, respectively). The OR for preeclampsia in hyperhomocysteinemia was 7.7 (95% CI: 1.7-34.8). CONCLUSION: Pregnant women with hyperhomocysteinemia have a 7.7-fold risk for preeclampsia (CI 95%: 1.7-34.8) compared with normal controls.
Authors: Alejandra Perez-Sepulveda; Pedro P España-Perrot; Errol R Norwitz; Sebastián E Illanes Journal: Reprod Sci Date: 2013-03-01 Impact factor: 3.060
Authors: Derrick L Chandler; Maria T Llinas; Jane F Reckelhoff; Babbette LaMarca; Joshua Speed; Joey P Granger Journal: Am J Hypertens Date: 2009-07-23 Impact factor: 2.689
Authors: Alejandra Pérez-Sepúlveda; Pedro P España-Perrot; Ximena B Fernández; Verónica Ahumada; Vicente Bustos; José Antonio Arraztoa; Aneta Dobierzewska; Horacio Figueroa-Diesel; Gregory E Rice; Sebastián E Illanes Journal: Biomed Res Int Date: 2013-08-20 Impact factor: 3.411