BACKGROUND: Early detection of bone metastases in prostatic carcinoma is very useful in treatment and prognosis of the disease. The aim of this work was to evaluate the sensitivity and specificity of a group of bone markers in order to discriminate between prostate carcinoma patients without (M(0)) and with (M(1)) bone metastases. METHODS: Sixty-seven non-treated patients with: benign prostate hyperplasia (n=21), prostatic carcinoma in several stages without bone metastases (T(X)M(0)) (n=31) and with bone metastases (T(X)M(1)) (n=15) were studied. The following markers were studied: (A) bone formation: (1) serum bone alkaline phosphatase, IRMA (Tandem Ostase, Beckman); (2) serum procollagen I amino-terminal propeptide (PINP), RIA (Orion Diagnostica); (B) bone resorption: (1) urinary collagen I amino-terminal telopeptide (NTX), ELISA (Ostex); (2) collagen I carboxy terminal telopeptide (CTX): (2A) urinary alpha-CTX, RIA (Osteometer), (2B) serum beta-CTX, Elecsys (Roche); (3) collagen I cross-linked carboxy terminal telopeptide (ICTP), RIA (Orion Diagnostica). RESULTS: Levels of all bone markers were significantly higher in group M(1) than in group M(0). A complete separation of groups M(0) and M(1) was achieved with PINP and beta-CTX (100% sensitivity and specificity). CONCLUSIONS: These results support the use of PINP or beta-CTX as a tool to confirm the presence or absence of bone metastases in the first staging of prostatic carcinoma patients.
BACKGROUND: Early detection of bone metastases in prostatic carcinoma is very useful in treatment and prognosis of the disease. The aim of this work was to evaluate the sensitivity and specificity of a group of bone markers in order to discriminate between prostate carcinomapatients without (M(0)) and with (M(1)) bone metastases. METHODS: Sixty-seven non-treated patients with: benign prostate hyperplasia (n=21), prostatic carcinoma in several stages without bone metastases (T(X)M(0)) (n=31) and with bone metastases (T(X)M(1)) (n=15) were studied. The following markers were studied: (A) bone formation: (1) serum bone alkaline phosphatase, IRMA (Tandem Ostase, Beckman); (2) serum procollagen I amino-terminal propeptide (PINP), RIA (Orion Diagnostica); (B) bone resorption: (1) urinary collagen I amino-terminal telopeptide (NTX), ELISA (Ostex); (2) collagen I carboxy terminal telopeptide (CTX): (2A) urinary alpha-CTX, RIA (Osteometer), (2B) serum beta-CTX, Elecsys (Roche); (3) collagen I cross-linked carboxy terminal telopeptide (ICTP), RIA (Orion Diagnostica). RESULTS: Levels of all bone markers were significantly higher in group M(1) than in group M(0). A complete separation of groups M(0) and M(1) was achieved with PINP and beta-CTX (100% sensitivity and specificity). CONCLUSIONS: These results support the use of PINP or beta-CTX as a tool to confirm the presence or absence of bone metastases in the first staging of prostatic carcinomapatients.
Authors: Christian Bieglmayer; Hans Peter Dimai; Rudolf Wolfgang Gasser; Stefan Kudlacek; Barbara Obermayer-Pietsch; Wolfgang Woloszczuk; Elisabeth Zwettler; Andrea Griesmacher Journal: Wien Med Wochenschr Date: 2012-08-14
Authors: C de la Piedra; A Alcaraz; J Bellmunt; C Meseguer; A Gómez-Caamano; M J Ribal; F Vázquez; U Anido; P Samper; E Esteban; J L Álvarez-Ossorio; P C Lara; L A San José; J A Contreras; A G del Alba; B González-Gragera; A J Tabernero; C González-Enguita; J M Fernández; A García-Escudero; F Gómez-Veiga; M J Méndez; J Segarra; J A Virizuela; J Carles; A Lassa; V Calderero; M Constela; D Delgado; A Mañas; A Murias; G Reynes; B Rodriguez; G Rubio; E Sánchez; M Unda; E Solsona; J M Martínez-Javaloyas; J Comet-Batlle; C Quicios; M Martín-Fernández; I Mahillo-Fernández; J Morote Journal: Br J Cancer Date: 2013-05-30 Impact factor: 7.640
Authors: Leonard Chiu; Erin Wong; Carlo DeAngelis; Nicholas Chiu; Henry Lam; Rachel McDonald; Natalie Pulenzas; Julia Hamer; Nicholas Lao; Edward Chow Journal: J Bone Oncol Date: 2015-02-27 Impact factor: 4.072