OBJECT: The behavior of brain tissue in cases of arteriovenous malformations (AVMs) is a matter of debate. The authors believe that the local microvascular environment in the AVM bed shares the hemodynamic changes influencing that behavior in one way or another. The purpose of this study was to investigate the microvascular pathological features in the immediate perinidal brain tissue. METHODS: This retrospective study was conducted using excised AVM specimens obtained in 35 patients, from which the authors selected 20 specimens that fulfilled the criteria for sufficient brain tissue around the excised nidus. Specimens were stained with hematoxylin and eosin, and the immediate perinidal microvascular environment was examined using light microscopy. CONCLUSIONS: Eighty-five percent of the AVMs studied showed the presence of huge, dilated capillaries, and 65% showed severe congestion of these capillaries. The authors have named these capillaries "giant bed capillaries." In this study capillary bleeding was shown in AVMs, and a pericapillary space was seen around some vessels. The brain parenchyma containing AVMs with these findings proved to be significantly ischemic.
OBJECT: The behavior of brain tissue in cases of arteriovenous malformations (AVMs) is a matter of debate. The authors believe that the local microvascular environment in the AVM bed shares the hemodynamic changes influencing that behavior in one way or another. The purpose of this study was to investigate the microvascular pathological features in the immediate perinidal brain tissue. METHODS: This retrospective study was conducted using excised AVM specimens obtained in 35 patients, from which the authors selected 20 specimens that fulfilled the criteria for sufficient brain tissue around the excised nidus. Specimens were stained with hematoxylin and eosin, and the immediate perinidal microvascular environment was examined using light microscopy. CONCLUSIONS: Eighty-five percent of the AVMs studied showed the presence of huge, dilated capillaries, and 65% showed severe congestion of these capillaries. The authors have named these capillaries "giant bed capillaries." In this study capillary bleeding was shown in AVMs, and a pericapillary space was seen around some vessels. The brain parenchyma containing AVMs with these findings proved to be significantly ischemic.
Authors: Ethan A Winkler; Harjus Birk; Jan-Karl Burkhardt; Xiaolin Chen; John K Yue; Diana Guo; W Caleb Rutledge; George F Lasker; Carlene Partow; Tarik Tihan; Edward F Chang; Hua Su; Helen Kim; Brian P Walcott; Michael T Lawton Journal: J Neurosurg Date: 2018-12-01 Impact factor: 5.115
Authors: Wanqiu Chen; Yi Guo; Espen J Walker; Fanxia Shen; Kristine Jun; S Paul Oh; Vincent Degos; Michael T Lawton; Tarik Tihan; Dimitrios Davalos; Katerina Akassoglou; Jeffrey Nelson; John Pile-Spellman; Hua Su; William L Young Journal: Arterioscler Thromb Vasc Biol Date: 2012-12-13 Impact factor: 8.311
Authors: Yongmei Chen; Qi Hao; Helen Kim; Hua Su; Michelle Letarte; S Ananth Karumanchi; Michael T Lawton; Nicholas M Barbaro; Guo-Yuan Yang; William L Young Journal: Ann Neurol Date: 2009-07 Impact factor: 10.422
Authors: Eun-Jung Choi; Espen J Walker; Fanxia Shen; S Paul Oh; Helen M Arthur; William L Young; Hua Su Journal: Cerebrovasc Dis Date: 2012-05-09 Impact factor: 2.762