OBJECTIVES: Environmental factors might be of importance for the dramatically increasing incidence of osteoporotic fractures. Persistent organochlorine compounds (POCs) have, in animal studies, impaired normal bone metabolism and resulted in increased bone fragility. The goal of this study was to assess whether a high dietary intake of POCs through fatty fish from the Baltic Sea may result in an increased incidence of osteoporotic fractures. METHODS: Fishermen and their wives from the Swedish east coast on the Baltic Sea (exposed) and west coasts (unexposed) constituted the study base. Information on vital status and hospitalization of persons with fractures from 1987 to 1996, classified according to the ninth revision of the International Classification of Diseases, was retrieved for 17,823 subjects through register linkages. The impact of coastal stretch on fracture incidence was assessed by Poisson regression models, with age and calendar year also being taken into account. RESULTS: There was a significantly increased incidence rate ratio (IRR: 2.29, 95% confidence intervals (CI): 1.23-4.28) for vertebral fractures among east-coast women, and a similar, but non-significant, similar tendency in men (IRR 1.45, 95% CI 0.74-2.84). Such cohort differences were not seen for any other fracture type. CONCLUSIONS: The results give some indirect support for the notion that a high dietary intake of POCs through fatty fish from the Baltic Sea might be a risk factor for vertebral fractures, but it cannot be excluded that confounding from differences in smoking habits might explain part of the observed effects. To clarify this, detailed individual information on exposure and potential confounders has to be ascertained.
OBJECTIVES: Environmental factors might be of importance for the dramatically increasing incidence of osteoporotic fractures. Persistent organochlorine compounds (POCs) have, in animal studies, impaired normal bone metabolism and resulted in increased bone fragility. The goal of this study was to assess whether a high dietary intake of POCs through fatty fish from the Baltic Sea may result in an increased incidence of osteoporotic fractures. METHODS: Fishermen and their wives from the Swedish east coast on the Baltic Sea (exposed) and west coasts (unexposed) constituted the study base. Information on vital status and hospitalization of persons with fractures from 1987 to 1996, classified according to the ninth revision of the International Classification of Diseases, was retrieved for 17,823 subjects through register linkages. The impact of coastal stretch on fracture incidence was assessed by Poisson regression models, with age and calendar year also being taken into account. RESULTS: There was a significantly increased incidence rate ratio (IRR: 2.29, 95% confidence intervals (CI): 1.23-4.28) for vertebral fractures among east-coast women, and a similar, but non-significant, similar tendency in men (IRR 1.45, 95% CI 0.74-2.84). Such cohort differences were not seen for any other fracture type. CONCLUSIONS: The results give some indirect support for the notion that a high dietary intake of POCs through fatty fish from the Baltic Sea might be a risk factor for vertebral fractures, but it cannot be excluded that confounding from differences in smoking habits might explain part of the observed effects. To clarify this, detailed individual information on exposure and potential confounders has to be ascertained.
Authors: E Grimvall; L Rylander; P Nilsson-Ehle; U Nilsson; U Strömberg; L Hagmar; C Ostman Journal: Arch Environ Contam Toxicol Date: 1997-04 Impact factor: 2.804
Authors: Ewa Wallin; Lars Rylander; Bo A G Jönssson; Thomas Lundh; Anders Isaksson; Lars Hagmar Journal: Osteoporos Int Date: 2005-10-19 Impact factor: 4.507
Authors: Martin J Ronis; James Watt; Casey F Pulliam; Ashlee E Williams; Alexander W Alund; Ezazul Haque; Gopi S Gadupudi; Larry W Robertson Journal: Arch Toxicol Date: 2019-12-09 Impact factor: 5.153
Authors: Susan Hodgson; Laura Thomas; Elena Fattore; P Monica Lind; Tobias Alfven; Lennart Hellström; Helen Håkansson; Grazia Carubelli; Roberto Fanelli; Lars Jarup Journal: Environ Health Perspect Date: 2008-09 Impact factor: 9.031
Authors: Suzanne Côté; Pierre Ayotte; Sylvie Dodin; Claudine Blanchet; Gert Mulvad; Henning S Petersen; Suzanne Gingras; Eric Dewailly Journal: Environ Health Date: 2006-12-21 Impact factor: 5.984
Authors: Ashlee E Williams; James Watt; Larry W Robertson; Gopi Gadupudi; Michele L Osborn; Michael J Soares; Khursheed Iqbal; Kim B Pedersen; Kartik Shankar; Shana Littleton; Cole Maimone; Nazmin A Eti; Larry J Suva; Martin J J Ronis Journal: Toxicol Sci Date: 2020-05-01 Impact factor: 4.849
Authors: Christian Sonne; Rune Dietz; Erik W Born; Frank F Riget; Maja Kirkegaard; Lars Hyldstrup; Robert J Letcher; Derek C G Muir Journal: Environ Health Perspect Date: 2004-12 Impact factor: 9.031
Authors: Brenda Eskenazi; Marcella Warner; Marcella Sirtori; Thomas Fuerst; Stephen A Rauch; Paolo Brambilla; Paolo Mocarelli; Alessandro Rubinacci Journal: Environ Health Perspect Date: 2013-11-15 Impact factor: 9.031