Literature DB >> 12689763

The coupling of a trkB tyrosine residue to LTP.

Patrik Ernfors1, Clive R Bramham.   

Abstract

Brain-derived neurotrophic factor (BDNF) and its receptor, trkB, activate cAMP-response-element-binding protein (CREB) and the transcription of genes that is crucial for long-term potentiation (LTP). Any of several signaling pathways activated by trkB could be required for LTP. A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma (PLCgamma) pathway in CREB activation and LTP maintenance.

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Year:  2003        PMID： 12689763     DOI： 10.1016/S0166-2236(03)00064-X

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  22 in total

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